1133215-75-4Relevant academic research and scientific papers
Warming Up to Oxazole: Noncryogenic Oxazole Metalation and Negishi Coupling Development
Calimsiz, Selcuk,Geier, Michael J.,Humphreys, Luke D.,Scott, Mark E.,Wang, Xiaotian
, p. 1776 - 1781 (2019/09/09)
This report details the development of several suitable noncryogenic metalation conditions for the synthesis of oxazole zincate. Subsequent rounds of high-throughput catalyst screening ultimately led to the identification of several suitable Pd sources th
Regioselective functionalization of the oxazole scaffold using TMP-bases of Mg and Zn
Haas, Diana,Mosrin, Marc,Knochel, Paul
supporting information, p. 6162 - 6165 (2014/01/17)
A general method for the synthesis of 2,4,5-trisubstituted oxazoles has been developed. Starting from commercially available oxazole, successive metalations using TMPMgCl·LiCl or TMPZnCl·LiCl led to the corresponding magnesiated or zincated species which
Highly regioselective palladium-catalyzed direct arylation of oxazole at C-2 or C-5 with aryl bromides, chlorides, and triflates
Strotman, Neil A.,Chobanian, Harry R.,Guo, Yan,He, Jiafang,Wilson, Jonathan E.
supporting information; experimental part, p. 3578 - 3581 (2010/11/04)
Complementary palladium-catalyzed methods for direct arylation of oxazole with high regioselectivity (>100:1) at both C-5 and C-2 have been developed for a wide range of aryl and heteroaryl bromides, chlorides, iodides, and triflates. C-5 arylation is pre
Nickel-catalyzed synthesis of oxazoles via C-S activation
Lee, Kyoungsoo,Counceller, Carla M.,Stambuli, James P.
supporting information; experimental part, p. 1457 - 1559 (2009/08/08)
The synthesis of 2-substituted oxazoles is achieved via nickel-catalyzed cross-coupling reaction of 2-methylthio-oxazole and various organozinc reagents. An extension of this method is demonstrated with a chemoselective, one-pot synthesis of unsymmetrical
