113322-08-0Relevant articles and documents
Coupling products of amino acids to penicillin V and cephalothin: Synthesis and susceptibility to carboxypeptidases and lysosomal enzymes
Bounkhala,Renard,Baurain,Marchand-Brynaert,Ghosez,Tulkens
, p. 976 - 983 (1988)
Amino acids have been coupled to the carboxyl group of penicillin V and cephalothin by methods that keep the β-lactam ring intact. Derivatives were successfully obtained with both neutral (Leu, Val, Ala, Ile, Trp, Tyr, Gly) and one acidic (Glu) amino acid