Coupling products of amino acids to penicillin V and cephalothin: Synthesis and susceptibility to carboxypeptidases and lysosomal enzymes

Article abstract of DOI:10.1021/jm00400a015

Amino acids have been coupled to the carboxyl group of penicillin V and cephalothin by methods that keep the β-lactam ring intact. Derivatives were successfully obtained with both neutral (Leu, Val, Ala, Ile, Trp, Tyr, Gly) and one acidic (Glu) amino acid