1133396-07-2

Upstream product

• 3179-10-0 1-methoxy-4-(2-nitro-vinyl)-benzene 
• 109-77-3 malononitrile 
• 123-11-5 4-methoxy-benzaldehyde 
• 75-52-5 nitromethane 
• 2826-26-8 2-(4-methoxyphenylmethylene)malononitrile 

Downstream Products

• 3179-10-0 (E)-1-methoxy-4-(2-nitrovinyl)benzene 

Relevant academic research and scientific papers

Cinchona alkaloid and di-: Tert -butyldicarbonate-DMAP promoted efficient synthesis of (E)-nitroolefins

The synthesis of nitroolefins from aldehydes and olefins is generally limited by the formation of a mixture of cis and trans compounds. Here we report an alternative, metal-free protocol for the synthesis of β-nitroolefins from arylidinemalononitrile using cinchona alkaloid along with di-tert-butyldicarbonate-DMAP in high yields with total selectivity.

Tris-ureas as versatile and highly efficient organocatalysts for Michael addition reactions of nitro-olefins: Mechanistic insight from in-situ diagnostics

Tris(2-aminoethyl)-amine, TREN based tris-ureas (1a–1d) and tris-thiourea (1e) have been explored towards a wide range of catalytic Michael addition reactions. These tris-ureas, 1a–1d efficiently catalyze the addition reaction of β-nitro styrenes (2a–2d)

Reduced graphene oxide supported piperazine in aminocatalysis

Reduced graphene oxide (rGO) has been used as a support for piperazine to provide a heterogeneous bifunctional organocatalyst (rGO-NH) that is able to efficiently promote vintage organic transformations such as Knoevenagel, Michael and aldol reactions. The obtained results suggest a significant role of the support in the course of these reactions. This journal is the Partner Organisations 2014.

Aqueous-mediated michael addition of active methylene compounds with nitroalkenes

A simple, atom economical and highly efficient green protocol has been developed for the synthesis of Michael adducts of nitroalkenes and 2-amino-2-chromene derivatives by Michael addition of active methylene compounds (such as malononitrile and ethyl cyanoacetate) to nitroalkenes under aqueous-mediated conditions. This green approach provided the desired products in high yields and the reaction scope proved to be quite broad.

Superoxide ion mediated Michael addition of active methylene compounds to nitroolefms

Michael addition of active methylene compounds to β-nitrostyrenes using in situ generated superoxide ion results in the formation of Michael adduct in 72-88% yield under mild reaction conditions, at room temperature.

Efficient method for the synthesis of Michael adducts using Kaolin preloaded with KOH

Michael addition of various active methylene compounds to β-nitrostyrenes is efficiently catalyzed by using Kaolin preloaded with KOH in acetonitrile at room temperature with moderate to good yields. Copyright Taylor & Francis Group, LLC.