113368-83-5

Upstream product

• 1125-88-8 benzaldehyde dimethyl acetal 
• 120187-98-6 (2R,3S)-4-Benzyloxy-2-vinyl-butane-1,3-diol 
• 593-60-2 Vinyl bromide 
• 81177-24-4 (S,S)-1,4-bis(benzyloxy)-2,3-epoxybutane 
• 1826-67-1 vinyl magnesium bromide 
• 123125-14-4 1,4-di-O-benzyl-2-chloro-2-deoxy-3-O-formyl-L-erythritol 
• 162434-98-2 1,4-di-O-benzyl-L-threitol 2,3-cyclic ethyl orthoformate 
• 78513-07-2 (-)-(2S,3R)-2,3-epoxy-4-(benzyloxy)-1-butanol 

Downstream Products

• 132121-56-3 (2S,3R)-1-Benzyloxy-3-benzyloxymethyl-4,5-epoxypentan-2-ol 
• 132121-59-6 (4S,5S)-4,5-Bis-benzyloxymethyl-tetrahydro-furan-3-ol 
• 113368-95-9 (Diisopropoxy-phosphoryl)-acetic acid (1R,2R)-1,2-bis-benzyloxymethyl-but-3-enyl ester 
• 114861-08-4 (3R,4R)-4,5-bis(phenylmethoxy)-3-<(phenylmethoxy)methyl>-1-pentene 
• 162434-99-3 (2R,3R)-1,4-bis(benzyloxy)-3-vinyl-2-butanol mesylate 
• 140160-47-0 ((1R,2R)-1,2-Bis-benzyloxymethyl-but-3-enyloxy)-tert-butyl-dimethyl-silane 
• 224581-29-7 (2R,3R)-4-Benzyloxy-2-benzyloxymethyl-butane-1,3-diol 
• 114861-10-8 (2R,3R)-3,4-bis(phenylmethoxy)-2-<(phenylmethoxy)methyl>-1-butanal 
• 114861-09-5 (2R,3R)-3,4-Bis-benzyloxy-2-benzyloxymethyl-butyraldehyde 
• 106799-10-4 4,5-anhydro-3-deoxy-3-<(phenylmethoxy)methyl>-1,2-bis-O-(phenylmethyl)galactitol 
• 106820-43-3 (4R,5R)-5,6-bis(phenylmethoxy)-4-<(phenylmethoxy)methyl>-2-hexen-1-ol 
• 159721-93-4 (2'S,3'S)-1-<2',3'-bis(benzyloxymethyl)azetidinyl>thymine 
• 162435-02-1 (2S,3R)-3-azido-1,4-bis(benzyloxy)-2-hydroxymethylbutane mesylate 
• 159721-90-1 (2'S,3'S)-1-<2',3'-bis(benzyloxymethyl)azetidinyl>uracil 

Relevant academic research and scientific papers

Synthesis of enantiomerically pure 9-[(1'R,2'R,3'S)-bis(hydroxymethyl)thietan-1'-yl]adenine, 3'-thio analog of oxetanocin A

The enantiomerically pure synthesis of 9-[(1'R,2'R,3'S)-bis(hydroxymethyl)thietan-1'-yl]adenine 2, 3'-thio analog of oxetanocin A, was achieved via coupling with sulfoxide 17 and 6-chloropurine in the presence of TMSOTf and Et3N under the Pummerer reaction conditions.

Synthesis of 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-α-L-threofuranosyl] adenine and its 4'-thio analog as potential antiviral agents

The enantiomerically pure synthesis or 9-[2',3'-dideoxy-2',3'-bis-C-hydroxymethyl-α-L- threofuranosyl]adenine and its 4'-thio analog was achieved via coupling of silylated 6-chloropurine with 1-O-acetylfuronase derivative 17 and its 4'-thio analog 24, respectively, prepared from (+)-diethyl L-tartrate.

Enantiospecific synthesis of [(2'S, 3'S)-bis(hydroxymethyl)azetidin-1-yl]pyrimidine nucleosides as potential antiviral agents

The enantiospecific synthesis of [(2'S, 3'S)-bis(hydroxymethyl)azatidin-1-yl]pyrimidine nucleotides 22, 25, and 27 was achieved via construction of the base on the 1-aminoacetidine 18 prepared from (+)-diethyl-L-tartrate, and they are the first members of

An improved, practical synthesis of the derivatives of 1-O-acetyl-2-deoxy-2-hydroxymethyl-D-erythrooxetanose, a key sugar moiety for the synthesis of oxetanosyl-N-glycoside

Intramolecular cyclization of the cis-epoxy-alcohol (6) with KOH in aq.DMSO provided predominantly the oxetane compound (7), which on oxidation followed by Baeyer-Villiger reaction gave 1-O-acetyl-D-erythrooxetanoses.

Total Synthesis of Amphoteronolide B and Amphotericin B. 1. Strategy and Stereocontrolled Construction of Key Building Blocks

The retrosynthetic analysis and strategy for the total synthesis of amphotericin B (1) and amphoteronolide B (2) is discussed.Focusing on subtle and repeated structural units, a retrosynthetic scheme was constructed that led to the recognition of readily