113372-69-3

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-Aminophenylalcohol is used as an intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows it to be a key component in the development of new drugs, contributing to the advancement of medical treatments.
Used in Agrochemical Industry:
In the agrochemical sector, 2-Chloro-4-Aminophenylalcohol serves as an intermediate in the production of agrochemicals. Its involvement in the synthesis process helps create effective products for agricultural applications, such as pesticides and herbicides.
Used in Dye and Pigment Production:
2-Chloro-4-Aminophenylalcohol is utilized in the manufacturing of dyes and pigments. Its chemical properties make it suitable for creating a wide range of colors and hues, which are essential in various industries, including textiles, plastics, and printing.
Used in Organic Synthesis:
2-Chloro-4-AMinophenylalcohol is also employed in organic synthesis, where it can be used to create a variety of organic compounds. Its versatility in chemical reactions makes it a valuable asset in the synthesis of complex organic molecules for research and industrial applications.

Upstream product

• 84228-44-4 methyl 4-amino-3-chlorobenzoate 
• 620-20-2 1-Chloro-3-chloromethyl-benzene 
• 77455-59-5 3-chloro-4-nitrobenzyl chloride 
• 21803-75-8 4-amino-3-chlorobenzonitrile 
• 113372-68-2 3-chloro-4-nitrobenzyl alcohol 
• 113372-67-1 3-chloro-4-nitrobenzyl benzoate 
• 2486-71-7 4-amino-3-chlorobenzoic acid 

Downstream Products

• 253863-32-0 C₆₁H₆₉ClN₆O₂₀ 
• 253863-31-9 Carbonic acid 4-{(S)-6-allyloxycarbonylamino-2-[(S)-2-((R)-2-allyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-hexanoylamino}-3-chloro-benzyl ester 4-nitro-phenyl ester 
• 253863-27-3 [(S)-5-[(S)-2-((R)-2-Allyloxycarbonylamino-propionylamino)-3-phenyl-propionylamino]-5-(2-chloro-4-hydroxymethyl-phenylcarbamoyl)-pentyl]-carbamic acid allyl ester 

Relevant academic research and scientific papers

Molybdenum hexacarbonyl and DBU reduction of nitro compounds under microwave irradiation

An ethanolic mixture of molybdenum hexacarbonyl and DBU mediates the reduction of nitroarenes to the corresponding anilines in excellent yields in 15-30 minutes under microwave irradiation. Georg Thieme Verlag Stuttgart.

NEW CYCLOHEXYLAMINE DERIVATIVES HAVING β2 ADRENERGIC AGONIST AND M3 MUSCARINIC ANTAGONIST ACTIVITIES

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

New cyclohexylamine derivatives having beta2 adrenergic agonist and m3 muscarinic antagonist activities

The present invention relates to novel compounds having β2 adrenergic agonist and M3 muscarinic antagonist dual activity, to pharmaceutical compositions containing them, to the process for their preparation and to their use in respiratory therapies.

Synthesis and biological evaluation of novel prodrugs of anthracyclines for selective activation by the tumor-associated protease plasmin

New prodrugs of daunorubicin and doxorubicin designed for selective activation by the serine protease plasmin are described. The low toxic prodrugs 3, 4, and 5 are converted to the corresponding cytotoxic drugs upon proteolysis by the tumor-associated protease plasmin. Application of a self- eliminating spacer was essential for enzyme activation. A prodrug containing a chloro-substituted spacer was synthesized with the aim of enhancing the rate of conversion by plasmin. All prodrugs were highly stable in buffer solution and in serum and on the average 15-fold less cytotoxic than the parent drugs in seven human tumor cell lines. A marked in vitro selectivity was demonstrated by incubation of the doxorubicin prodrugs with a plasmin generating MCF-7 breast cancer cell line transfected with urokinase-type plasminogen activator (u-PA) in comparison with the nontransfected nonplasmin generating cell line. Prodrugs 4 and 5 showed the same cytotoxic effect as the free parent drug doxorubicin in the u-PA transfected cells, indicating complete conversion of the prodrug by plasmin. Addition of the plasmin inhibitor Trasylol drastically increased the ID50 values in the u-PA transfected MCF-7 cells for both prodrugs 4 and 5.

THE SYNTHESIS OF 3-CHLORO-4-NITRO- AND 4-AMINO-3-CHLORO-BENZYL ALCOHOLS

The synthesis of the new compounds 3-chloro-4-nitro- and 4-amino-3-chloro-benzyl alcohols is described.Nitration of 3-chloro-benzyl chloride gives two isomers; the 3-chloro-4-nitrobenzyl chloride isomer is converted to the alcohol via an ester intermediat