113379-18-3

Upstream product

• 57822-33-0 1-iodo-3-(m-methoxyphenyl)propane 
• 105-53-3 diethyl malonate 
• 7252-82-6 3-(3-methoxyphenyl)propan-1-ol 
• 6943-97-1 (m-methoxyphenyl)propyl bromide 
• 6099-04-3 trans-3-methoxycinnamic acid 
• 64-17-5 ethanol 
• 95207-56-0 <3-(3-methoxyphenyl)propyl>malonic acid 

Downstream Products

• 6500-65-8 2-methoxy-6,7,8,9-tetrahydro-benzocyclohepten-5-one 
• 66004-20-4 5-(3-methoxyphenyl)pentan-1-ol 
• 111171-92-7 5-(3-methoxyphenyl)pentanal 
• 111171-82-5 5-(m-methoxyphenyl)-1,1-bis(phenylthio)pentane 
• 111171-81-4 5-(m-methoxyphenyl)-1,1,1-tris(phenylthio)pentane 
• 123958-41-8 4-oxatetracyclo[8.2.2.12,5.09,15]pentadeca-2,5,7,9(15),13-pentaene-11,11,12,12-tetracarbonitrile 
• 123958-40-7 (5-oxo-5H-benzocyclohepten-4-yloxy)acetic acid 
• 123971-76-6 5-(2-bromo-5-methoxyphenyl)pentanoic acid 
• 123958-37-2 4-acetoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one 
• 123958-36-1 1-bromo-4-methoxy-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-one 
• 6500-64-7 5-(3'-methoxyphenyl)pentanoic acid 
• 113379-19-4 2-[3-(3-Hydroxy-phenyl)-propyl]-malonic acid 
• 113378-93-1 diethyl <3-(3-hydroxyphenyl)propyl>malonate 
• 111171-91-6 ethyl 5-(m-methoxyphenyl)pentanoate 

Relevant academic research and scientific papers

Inhibitors of prenyl-protein transferase

The present invention is directed to peptidomimetic macrocyclic compounds which inhibit prenyl-protein transferase and the prenylation of the oncogene protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting prenyl-protein transferase and the prenylation of the oncogene protein Ras.

Furan Derivatives. Part 10. Synthesis of Cycloheptabenzofuran

Cycloheptabenzofuran 2 was synthesized by heating (5-oxo-5H-benzocyclohepten-4-yloxy)acetic acid 16 with sodium acetate in acetic anhydride or by photocyclization of 16 in acetonitrile.Several reactions of cycloheptabenzofuran 2 were examined.Protonation of 2 with trifluoroacetic acid occurred at the 2-position to give a tropylium ion 17.Catalytic hydrogenation of 2 with palladium on charcoal proceeded smoothly to give tetrahydrocycloheptabenzofuran 18.The Diels-Alder reaction of 2 with tetracyanoethylene produced an adduct 19.Formylation of 2 with phosphorus oxychloride and dimethylformamide occurred easily at the 2-position to afford compound 20.Cycloheptabenzofuran 2 has both properties of heptafulvene and benzofuran.

AROMATIC ANNULATION WITH BISPHENYLTHIONIUM IONS

The chemospecific production and intramolecular aromatic electrophilic substitution (annulation) of bis(phenylthio)carbocations (bisphenylthionium ions) has been studied using appropriate model compounds.The annulation reaction is very sensitive to the Lewis acid initiator and also the solvent.The best reaction conditions were found to be a suspension of silver trifluoromethanesulfonate in dichloromethane.Annulation of six-membered rings onto alkylbenzene and five- and seven-membered rings onto activated benzenes have been achieved.