1133874-06-2Relevant academic research and scientific papers
A thiophene alkylorthonate / - hetero aromatic ring structure of synthetic method
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Paragraph 0125; 0237-0239, (2017/12/04)
The invention discloses a synthesis method for a thiophene ring/furan ring-heteroaromatic ring structure. Specifically, according to the synthesis method provided by the invention, various high-yield thiophene ring/furan ring-heteroaromatic ring building block compounds are prepared from thiophene ring or furan ring or derivatives thereof and heteroaromatic ring compounds in the prescence of palladium salt and oxidant. The synthesis method has the advantages of simple and readily available raw materials, small using amount of catalysts, wide application range of substrates, simplicity and convenience in operation, high reaction efficiency and the like. The prepared thiophene ring/furan ring-heteroaromatic ring building blocks are widely applied in the aspects of photoelectric materials, luminescent agents, solar batteries and the like.
Development of dual targeting inhibitors against aggregations of amyloid-β and tau protein
Fuse, Shinichiro,Matsumura, Keisuke,Fujita, Yuki,Sugimoto, Hachiro,Takahashi, Takashi
, p. 228 - 234 (2014/08/18)
Aggregations of both amyloid-β (Aβ) and hyper-phosphorylated tau proteins are recognized as key pathological manifestations of Alzheimer's disease (AD). Agents that inhibit both those forms of aggregation show promise as drug candidates. Seventeen oligo h
Pd-catalyzed oxidative cross-coupling between two electron rich heteroarenes
He, Chun-Yang,Wang, Zhen,Wu, Cai-Zhi,Qing, Feng-Ling,Zhang, Xingang
, p. 3508 - 3513 (2013/11/19)
The transition-metal-catalyzed oxidative cross-coupling between two coupling partners with similar structure and electronic characteristics remains a challenge owing to difficulty in suppressing undesired homo-couplings. We herein report a Pd-catalyzed oxidative cross-coupling between two thiophenes under mild reaction conditions. This approach can also be extended to furans. Some notable advantages of this reaction lie in its synthetic simplicity with the omission of the toxic stannanes coupling partner and excellent functional-group compatibility. The features of this protocol make it an ideal strategy for the construction of a 2,2′-thiophene-thiophene linkage of interest in electronic and optoelectronic materials.
Synthesis of 5-aryl-5′-formyl-2,2′-bithiophenes as new precursors for nonlinear optical (NLO) materials
Herbivo, Cyril,Comel, Alain,Kirsch,Raposo, M. Manuela M.
experimental part, p. 2079 - 2086 (2009/07/18)
A series of formyl-substituted 5-aryl-2,2′-bithiophenes 5 were synthesized using two different methods: Vilsmeier-Haack-Arnold reaction (VHA) or through Suzuki coupling. The synthesis of compounds 5 through the Vilsmeier-Haack-Arnold reaction, starting from inexpensive and easily available precursors such as acetophenones, gave the title compounds in low yields after four reaction steps. On the other hand Suzuki coupling of functionalized arylboronic acids 7 and the 5-bromo-5′-formyl-2,2′-bithiophene 6 gave compounds 5 in good yields in only one step.
