113408-47-2

Upstream product

• 1499-55-4 L-glutamic acid 5-methyl ester 
• 76-83-5 trityl chloride 
• 109-89-7 diethylamine 

Downstream Products

• 680601-93-8 methyl N-benzyl-N-(tert-butoxycarbonylamino)-δ-hydroxy-L-norvalinate 
• 680601-89-2 N-benzyl-δ-hydroxy-L-norvaline 

Relevant academic research and scientific papers

Electrophilic Amination of Amino Acids with N-Boc-oxaziridines: Efficient Preparation of N-Orthogonally Diprotected Hydrazino Acids and Piperazic Acid Derivatives

A general two-step preparation of enantiopure Nα,N β-orthogonally diprotected α-hydrazino acids 1 is developed on a multigram scale. The key reaction is the efficient electrophilic amination of N-benzyl amino acids 6 with N-Boc-oxaziridine 7 and accommodates various functional groups encountered in side chains of amino acids. The cyclic 2,3,4,5-tetrahydro-3-pyridazine carboxylic acid (piperazic acid) derivatives 2 and 3 or the cyclic 3,4-dihydro-3-pyrazolecarboxylate 4 are conveniently prepared from glutamic acid or aspartic acid via orthogonally diprotected α-hydrazino acids 1m and 1n.