113410-75-6Relevant articles and documents
Chemoselective formation of symmetrically linked bisisoxazole units: Steps toward isoxazoline/isoxazolidine based macrocycles
McKiernan, Margaret T.,Heaney, Frances
, p. 4597 - 4600 (1996)
Symmetrically linked bisisoxazole derivatives can be formed from a chemoselective one-pot three component reaction between oximes, dipole generating and dipole trapping components. The use of bifunctional dipole generating moieties affords bisisoxazolines (11), linked through their N- atoms. The employment of bifunctional dipolarophitic agents leads to bisisoxazolidines (3 and 4) linked via their C-5 carbon atoms.
Cycloaddition Reactions of Oximes; Powerful New Carbon-Carbon Bond Forming Methodology
Armstrong, Paul,Grigg, Ronald,Warnock, William J.
, p. 1325 - 1327 (2007/10/02)
Oximes react with Michael acceptors and dipolarophiles, usually regio- and stereo-specifically, via a tandem Michael addition-1,3-dipolar cycloaddition process, to give isoxazolidines in good yield; analysis of the tandem process identifies four broad syn
