2956-58-3Relevant academic research and scientific papers
Drug nanoparticles by emulsion-freeze-drying via the employment of branched block copolymer nanoparticles
Wais, Ulrike,Jackson, Alexander W.,Zuo, Yanming,Xiang, Yu,He, Tao,Zhang, Haifei
, p. 141 - 150 (2016)
A large percentage of drug compounds exhibit low water solubility and hence low bioavailability and therapeutic efficacy. This may be addressed by preparation of drug nanoparticles, leading to enhanced dissolution rate and direct use for treatment. Various methods have been developed to produce drug nanocrystals, including wet milling, homogenization, solution precipitation, emulsion diffusion, and the recently developed emulsion freeze-drying. The drawback for these methods may include difficult control in particles size, use of surfactants & polymer, and low ratio of drug to stabilizer. Here, biocompatible branched block copolymer nanoparticles with lightly-crosslinked hydrophobic core and hydrophilic surface groups are synthesized by the direct monomer-to-particle methodology, characterized, and then used as scaffold polymer/surfactant to produce drug nanoparticles via the emulsion-freeze-drying approach. This method can be used for model organic dye and different poorly water-soluble drugs. Aqueous drug nanoparticle dispersions can be obtained with high ratio of drug to stabilizer and relatively uniform nanoparticle sizes.
A photopolymerization initiator, and ink composition using the same
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Paragraph 0164; 0165, (2017/02/24)
PROBLEM TO BE SOLVED: To provide a compound useful as a water soluble photopolymerization initiator, and an ink composition containing the same.SOLUTION: A compound is represented by general formula (1) [in general formula (1), each of Rto Rindependently represents a hydrogen atom or a substituent, however, at least one of Rto Ris a group represented by R-X-* (wherein Xrepresents an oxygen atom or a sulfur atom, Rrepresents a substituent, and * represents a site connecting with a benzene ring), also Rrepresents a substituent other than an aryl group and a heterocyclic group, and two or more Rs may be identical to or different from one another].
Dental materials based on polyfunctional amides
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Page/Page column 13, (2008/06/13)
Dental material containing an amide of the general formula BXn in which B stands for a hydrocarbon radical with 1 to 5 carbon atoms, which can contain one or more of the groups O, S, NH, CO—NH, O—CO—NH and/or NH—CO—NH, and which is substituted n times with the group X, X stands for the group which is bound via the nitrogen atom or via C-2 to the radical B, the bond site not connected to B carrying a radical R2, R1 being hydrogen, an alkyl group with 1 to 20 carbon atoms or a phenyl radical, two or more radicals X being able to share a radical R1 and R1 also being able to be a constituent of the radical B, R2 being hydrogen, an alkyl group with 1 to 20 carbon atoms or a phenyl radical, and n being a number from 2 to 5.
One step process for preparing cross-linked poly-β-alanine microspheres from acrylamide and a copolymerisable polyfunctional compound
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, (2008/06/13)
A one-step process for preparing cross-linked poly-β-alanine as microspheres having narrow size distribution comprises polymerizing acrylamide with a polyfunctional compound copolymerizable with acrylamide (with the polyfunctional compound also acting as the cross-linking agent) in an organic solvent or a mixtured such solvents in the presence of an ionic polymerization initiator and a suspension agent. The resulting microspheres may be impregnated with a pharmaceutically or cosmetically active substance.
Process for the production of N-substituted acrylic acid amides
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, (2008/06/13)
The present invention relates to a process for the production of N-substituted acrylic acid amides by conversion of 2-carboalkoxy-t-oxabicyclo(2,2,1)hept-5-enes with primary or secondary amines to 2-carboxamide-7-oxabicyclo(2,2,1)hept-5-enes and the thermal decomposition of the latter, preferably in the presence of Lewis acids and in a vacuum, to furane and N-substituted acrylic acid amides. The process according to the invention results in high purity N-substituted acrylic acid amides that are, in the main, free of bifunctional monomers which would disrupt the subsequent polymerization of the N-substituted acrylic acid amides by undesired cross-linking.
Peptide Synthesis. Part 1. Preparation and Use of Polar Supports based on Poly(dimethylacrylamide)
Arshady, Reza,Atherton, Eric,Clive, Derek L. J.,Sheppard, Robert C.
, p. 529 - 537 (2007/10/02)
Details are given of the preparation of two functionalised polar support materials based on poly(dimethylacrylamide).Their solvation and other properties make them particularly suitable for solid-phase synthesis of polar substances, particularly of peptides and oligonucleotides, and also for solid-phase peptide and protein sequencing.Procedures are described for solid-phase peptide synthesis and are illustrated by preparation of a decapeptide.
