1134366-03-2Relevant academic research and scientific papers
The highly enantioselective phase-transfer catalytic mono-alkylation of malonamic esters
Kim, Mi-Hyun,Choi, Sea-Hoon,Lee, Yeon-Ju,Lee, Jihye,Nahm, Keepyung,Jeong, Byeong-Seon,Park, Hyeung-Geun,Jew, Sang-Sup
supporting information; experimental part, p. 782 - 784 (2009/07/10)
The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-α-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality. The Royal Society of Chemistry.
