924-61-8

Upstream product

• 105-53-3 diethyl malonate 
• 1608-26-0 Hexamethylphosphorous triamide 
• 105-36-2 ethyl bromoacetate 
• 124-40-3 dimethyl amine 
• 36239-09-5 ethyl chlorocarbonylacetate 
• 1071-46-1 hydrogen ethyl malonate 

Downstream Products

• 71509-16-5 4-methylamino-6-phenyl-6H-pyrano[3,2-c]quinoline-2,5-dione 
• 157724-83-9 α-N,N-dimethylcarbamoyl-3,5-dimethoxy-4-hydroxycinnamic acid 
• 1134366-03-2 (S)-2-benzyl-N,N-dimethylmalonamic acid ethyl ester 
• 913239-78-8 2-(7-chloro-9-methyl-2-phenyl-9H-pyrimido[4,5-b]indol-4-yl)-N,N-dimethylacetamide 
• 913240-25-2 ethyl 2-(7-chloro-9-methyl-2-phenyl-9H-pyrimido[4,5-b]indol-4-yl)-3-(dimethylamino)-3-oxopropanoate 
• 20929-39-9 N,N-Dimethyl-methyl-benzylmalonamidsaeureaethylester 
• 20929-38-8 N,N-Dimethyl-benzylmalonamidsaeuremethylester 
• 24011-69-6 2-(N-Dimethylcarbamoyl)-3-oxo-2,3-dihydro-benzoxazin-1,4 
• 26727-06-0 N,N-dimethyl-2-(2-nitro-phenoxy)-malonamic acid ethyl ester 
• 83767-08-2 8-benzil-2-(dimetilammino)cromone 
• 83767-06-0 6-benzil-2-(dimetilammino)cromone 
• 83767-00-4 2-(dimetilammino)-7-fenilcromone 
• 83766-97-6 2-(dimetilammino)-6-fenilcromone 
• 83767-03-7 2-(dimethylamino)-8-phenylchromone 

Relevant academic research and scientific papers

New succinate derivatives

The invention relates generally to new compounds of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 are independently of one another and denote hydrogen, hydroxyl, C1- C6-alkyl group or R6 and R7 form together a C5-C6 ring system, and wherein n = 0, 1, 2,

NEW SUCCINATE DERIVATIVES

The invention relates generally to new compounds of formula (I), wherein R1, R'1, R2, R'2, R3, R'3, R4 R'4, R5, R'5, R6, R7

The highly enantioselective phase-transfer catalytic mono-alkylation of malonamic esters

The phase-transfer catalytic alkylation of N,N-dialkylmalonamic tert-butyl esters in the presence of 1 mol% of (S,S)-3,4,5-trifluorophenyl-NAS bromide afforded highly enantioselective (S)-mono-α-alkylated products (up to 96% ee), which could be readily converted into versatile chiral building blocks without loss of chirality. The Royal Society of Chemistry.

trans-directing ability of amide groups in cyclopropanation: Application to the asymmetric cyclopropanation of alkenes with diazo reagents bearing two carboxy groups

(Chemical Equation Presented) Highly stereoselective: A highly enantioselective (up to 97 % ee) and diastereoselective (>30:1 d.r.) Rh II-catalyzed cyclopropanation of alkenes using a diazo reagent bearing two carboxy groups is described. This new methodology exploits the powerful trans-directing ability of amides to improve enantiocontrol. Mono- and disubstituted olefins are cyclopropanated in good yields. nttl=N-1,8-naphthoyl- tert-leucine.

New indium-mediated cyclisation reactions of tethered haloenynes in aqueous solvent systems

The intramolecular cyclisation of tethered allyl bromides onto terminal alkynes mediated by metallic indium proceeds smoothly and cleanly in mixtures of THF and H2O to give unsaturated carbocycles and heterocycles in good yield. Alternatively, the cyclisation may be carried out in anhydrous THF with the aid of acid catalysis. The reaction is also mediated by a range of indium salts and proceeds with substoichiometric quantities of indium in the presence of a co-reductant. Deuteration studies show that the reaction proceeds via a concerted syn carboindination of the carbon-carbon triple bond to give an intermediate, which is protonated in situ.