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113450-48-9

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113450-48-9 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 113450-48-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,3,4,5 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 113450-48:
(8*1)+(7*1)+(6*3)+(5*4)+(4*5)+(3*0)+(2*4)+(1*8)=89
89 % 10 = 9
So 113450-48-9 is a valid CAS Registry Number.

113450-48-9Downstream Products

113450-48-9Relevant articles and documents

DNA interaction and anticancer properties of new peripheral phthalocyanines carrying tosylated 4-morpholinoaniline units

?mero?lu, ?pek,?zel, Arzu,ünver, Yasemin,Barut, Burak,Durmu?, Mahmut,Ertem, Beytullah,Kantekin, Halit,Yal??n, Can ?zgür,Yalazan, Halise

, (2020)

In this paper, tosylated 4-morpholinoaniline units fused peripherally tetra-substituted free-base (5), copper(II) (6), zinc(II) (7), cobalt(II) (8) and magnesium(II) (9) phthalocyanines (Scheme 1) were reported and these new phthalocyanine conjugates were characterized through Fourier Transform–Infrared (FT–IR) with ATR sampling accessory, Mass Spectra Analysis [Matrix Assisted Laser Desorption/Ionization–Time of Flight–Mass Spectral (MALDI–TOF–MS)] and Ultraviolet–visible (UV–vis) (for all new phthalocyanines), elemental analysis, as well as 1H and 13C NMR spectroscopic techniques [for the compounds (2), (4), (5), (7) and (9)]. The potential utilization of the new peripheral phthalocyanine compounds (7–9) as the new pharmaceutical agents in PDT applications (in oncology and molecular biology) were determined in aspects of pBR322 plasmid DNA cleavage on agarose gel electrophoresis. The results showed that compound (7) cleaved pBR322 plasmid DNA with irradiation. Compound (7) displayed hypochromism without any shift on the addition of increasing concentrations of ct-DNA and Kb of compound (7) was calculated as 2.45 ± (0.20) × 104 M?1. In photochemical studies, the ΦΔ value of compound (7) was determined as 0.11. The cytotoxic/phototoxic properties of compound (7) which had the best photocleavage effects among tested compounds were investigated using MTT assay toward human colorectal (HCT-116) and cervical (HeLa) cancer cells. The cell viabilities of compound (7) were found to be 73 ± 1.6% (HCT-116) and 65 ± 5.5% (HeLa) at 100 μM with irradiation.

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