1135026-91-3

Basic information

• Product Name: 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one
• Synonyms: 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one
• CAS NO: 1135026-91-3
• Molecular Weight: 399.874
• Mol File: 1135026-91-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one(1135026-91-3)
• EPA Substance Registry System: 3-chloro-2-{[3-(tetrahydro-2H-pyran-4-ylmethoxy)phenoxy]methyl}quinolin-4(1H)-one(1135026-91-3)

Safety Data

• Hazardous Substances Data: 1135026-91-3(Hazardous Substances Data)

Upstream product

• 13720-90-6 4-oxo-1,4-dihydroquinoline-2-carboxylic acid ethyl ester 
• 16377-66-5 ethyl 3-chloro-4-oxo-1,4-dihydroquinoline-2-carboxylate 
• 1135036-99-5 C₂₉H₂₈ClNO₄ 
• 1135033-39-4 C₁₇H₁₄ClNO₂ 
• 1135033-31-6 C₁₇H₁₂ClNO₂ 
• 1135030-73-7 ethyl 4-(benzyloxy)-3-chloroquinoline-2-carboxylate 
• 1135035-14-1 3-(tetrahydro-2H-pyran-4-ylmethoxy)phenol 
• 1135033-45-2 C₁₇H₁₃Cl₂NO 

Relevant articles and documents

Identification of 4-quinolone derivatives as inhibitors of reactive oxygen species production from human umbilical vein endothelial cells

Oxidative stress is widely recognized as being associated with a number of disorders, including metabolic dysfunction and atherosclerosis. A series of substituted 4-quinolone derivatives were prepared and evaluated as inhibitors of reactive oxygen species (ROS) production from human umbilical vein endothelial cells (HUVECs). One compound in particular, 2-({[4-(3-hydroxy-3-methylbutoxy) pyridin-2-yl]oxy}methyl)-3-methylquinolin-4(1H)-one (25b), inhibited ROS production from HUVECs with an IC50 of 140 nM. This compound also exhibited low CYP2D6 inhibitory activity, high aqueous solubility, and good in vitro metabolic stability. An in vivo pharmacokinetic study of this compound in SD rats revealed high oral bioavailability and a long plasma half-life.