1135197-53-3Relevant academic research and scientific papers
Novel Cephalosporins Selectively Active on Nonreplicating Mycobacterium tuberculosis
Gold, Ben,Smith, Robert,Nguyen, Quyen,Roberts, Julia,Ling, Yan,Lopez Quezada, Landys,Somersan, Selin,Warrier, Thulasi,Little, David,Pingle, Maneesh,Zhang, David,Ballinger, Elaine,Zimmerman, Matthew,Dartois, Véronique,Hanson, Paul,Mitscher, Lester A.,Porubsky, Patrick,Rogers, Steven,Schoenen, Frank J.,Nathan, Carl,Aubé, Jeffrey
, p. 6027 - 6044 (2016/07/26)
We report two series of novel cephalosporins that are bactericidal to Mycobacterium tuberculosis alone of the pathogens tested, which only kill M. tuberculosis when its replication is halted by conditions resembling those believed to pertain in the host, and whose bactericidal activity is not dependent upon or enhanced by clavulanate, a β-lactamase inhibitor. The two classes of cephalosporins bear an ester or alternatively an oxadiazole isostere at C-2 of the cephalosporin ring system, a position that is almost exclusively a carboxylic acid in clinically used agents in the class. Representatives of the series kill M. tuberculosis within macrophages without toxicity to the macrophages or other mammalian cells.
Design and synthesis of new cephalosporin antibiotics
Liu, Chunjing,Dutta, Dinah,Mitscher, Lester
, p. 633 - 638 (2014/04/03)
Cephalosporins are important antibiotics. We synthesized new cephalosporin analogs containing novel side chains of methyl, propyl, benzyl, and phenoxy groups. Four synthetic methods with N-alkylation and N-acylation at position C-7 and esterification at position C-4 of 7-aminodesacetoxycephalosporanic acid are reported here. Graphical Abstract: [Figure not available: see fulltext.]
