propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Base Information

Chemical Name:propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
CAS No.:1135197-53-3
Molecular Formula:C₁₉H₂₂N₂O₅S
Molecular Weight:390.46
Hs Code.:

Synonyms:propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Chemical Property of propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

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Technology Process of propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

There total 5 articles about propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 10209-12-8
potassium (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

: 107-08-4
1-iodo-propane

: 1135197-53-3
propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: In N,N-dimethyl-formamide; at 20 ℃; for 12h;
DOI:10.1007/s00706-014-1152-6

Reference yield: 59.0%

: 10209-11-7
(6R,7R)-3-Methyl-8-oxo-7-(2-phenoxy-acetylamino)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid

: 107-08-4
1-iodo-propane

: 1135197-53-3
propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃; for 16h;
DOI:10.1021/acs.jmedchem.5b01833

Reference yield:

: 701-99-5
Phenoxyacetyl chloride

: 1135197-53-3
propyl (6R,7R)-3-methyl-8-oxo-7-(2-phenoxyacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / water; acetone / 0.35 h / 10 - 15 °C

1.2: 10 - 15 °C / pH 2

2.1: potassium 2-ethylhexanoate / butan-1-ol / 0.08 h

3.1: N,N-dimethyl-formamide / 12 h / 20 °C

With sodium hydrogencarbonate; potassium 2-ethylhexanoate; In water; N,N-dimethyl-formamide; acetone; butan-1-ol;
DOI:10.1007/s00706-014-1152-6