1135347-70-4Relevant academic research and scientific papers
Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity
Li, Yiwei,Liang, Jun,Siu, Tony,Hu, Essa,Rossi, Michael A.,Barnett, Stanley F.,Defeo-Jones, Deborah,Jones, Raymond E.,Robinson, Ronald G.,Leander, Karen,Huber, Hans E.,Mittal, Sachin,Cosford, Nicholas,Prasit, Peppi
, p. 834 - 836 (2009)
A series of [1,2,4]triazolo[3,4-f][1,6]naphthyridine allosteric dual inhibitors of Akt1 and 2 have been developed. These compounds have been shown to have potent dual Akt1 and 2 cell potency. The representative compound 13 provided potent inhibitory activity against Akt1 and 2 in vivo in a mouse model.
