113557-11-2Relevant academic research and scientific papers
Asymmetric alkylation or silylation of (S)-(-)-diphenylprolinol-derived α-silyl amide to synthesize optically pure α-monosilyl or bis(silyl) amides
Huang, Zhenggang,Gao, Lu,Song, Zhenlei
, p. 2861 - 2864 (2016)
Asymmetric alkylation or silylation of (S)-(-)-diphenylprolinol-derived α-silyl amide has been developed to synthesize optically pure α-monosilyl or bis(silyl) amides in good yields with high diastereoselectivity.
Enantioselective Carbon-Carbon Bond Formation by Chiral Organotitanium Compounds; Methyltitanium (S)-N-Acylpyrrolidinyl-methoxide Diisopropoxides
Takahashi, Hiroshi,Kawabata, Akihiro,Higashiyama, Kimio
, p. 1604 - 1607 (2007/10/02)
New chiral compounds, (S)-N-acylpyrrolidinylmethanols (1b-f and 1h), were synthesized and chiral methyltitanium diisopropoxides (2a-h) were prepared from 1a-h.Enantioselective carbon-carbon bond formation between aromatic carbaldehydes and 2a-h was achieved in yields of 90-97 percent and 10.5-54.1 percent ee.The chiral auxiliaries (1a-h) were recovered in almost quantitative yields without any loss of optical purity.Keywords: (S)-N-acylpyrrolidinylmethanol; carbon-carbon bond formation; enantioselective reaction; methyltitanium diisopropoxide; (R)-1-(1-naphthyl)ethanol; (R)-1-phenylethanol; (S)-prolinol
