113617-63-3Relevant articles and documents
Preparation method of photoinitiator
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Paragraph 0074-0105, (2021/10/13)
The invention discloses a preparation method of a photoinitiator. The preparation method comprises the following steps: acid chloride required for Fries reaction, aluminum trichloride and a solvent are mixed and then subjected to a Fourier reaction with benzene. Fries reaction intermediate purification method The Fourier reaction intermediate is mixed with chlorine for chlorination reaction, and the product of the chlorination reaction is subjected to gas-liquid separation to separate the gas. Reaction Section Step and The product purification step results in a photoinitiator finished product. To the technical scheme of the invention, the advantages of the traditional process of producing the photoinitiator are combined with the characteristics of the microchannel reactor to realize continuous preparation, the productivity can be improved, the production risk is reduced, the manpower and equipment investment are reduced, and the cost is further reduced.
Synthesis method of photoinitiator 1-hydroxycyclohexyl phenyl ketone
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Paragraph 0023-0028, (2020/12/05)
The invention aims to solve the technical problems of an existing alpha-hydroxycyclohexyl phenyl ketone synthesis method, provides a synthesis method of a photoinitiator 1-hydroxycyclohexyl phenyl ketone, and belongs to the technical field of chemical synthesis. The synthesis method comprises the following steps: (1) reacting a halogenated benzene with magnesium particles to prepare a Grignard reagent, dropwise adding cyclohexylcarbonitrile into the prepared Grignard reagent, and after the reaction is completed, hydrolyzing to generate cyclohexyl phenyl ketone; and (2) reacting cyclohexyl phenyl ketone with chlorine to obtain 1-chlorocyclohexyl phenyl ketone, and carrying out a hydrolysis reaction on the 1-chlorocyclohexyl phenyl ketone and a sodium hydroxide aqueous solution under the action of a catalyst to obtain 1-hydroxycyclohexyl phenyl ketone. The method is simple in synthesis process, high in yield and suitable for industrial production.
A austria peso star synthetic method
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Paragraph 0019; 0022; 0025-0030, (2017/08/10)
The present invention discloses an orbifloxacin synthesis method, which comprises: adopting sparfloxacin as a raw material, carrying out a diazotization reaction under the effect of hydrochloric acid and sodium nitrite to obtain a diazonium salt solution, adding tetrafluoroboric acid to the diazonium salt solution in a dropwise manner, carrying out a fluorization reaction at a temperature of -10 DEG C, filtering the reaction solution after completing the reaction, taking the filter cake, washing with ethyl ether, drying, heating the dried product until no gas is generated to obtain an orbifloxacin crude product, and purifying the orbifloxacin crude product to obtain the orbifloxacin. According to the present invention, the sparfloxacin is utilized as the starting raw material and the diazotization reaction and the fluorization reaction are used to prepare the orbifloxacin, such that advantages of new process route, high product yield, low reaction cost and short reaction time are provided, and the method is the new economical and practical technology.