113642-07-2

Upstream product

• 99548-53-5 3-Bromo-4-ethylbenzoic acid 
• 619-64-7 p-ethylbenzoic acid 

Downstream Products

• 113642-08-3 2'-bromo-4'-tert-butylcarboxylacetophenone 
• 113641-99-9 o-bromo-p-(t-butoxycarbonyl)acetophenone trimethylsilyl enol ether 
• 113642-12-9 t-butyl m-bromo-p-<1-hydroxy-2-(4-oxoazetidin-2-yl)ethyl>benzoate 
• 113642-00-5 t-butyl m-bromo-p-<(4-oxoazetidin-2-yl)acetyl>benzoate 
• 113642-01-6 3-Bromo-4-(1-trimethylsilanyloxy-vinyl)-benzoic acid benzyl ester 
• 113642-15-2 t-butyl p-<1-acetoxy-2-(4-oxoazetidin-2-yl)ethyl>-m-bromo-benzoate 
• 113642-02-7 benzyl m-bromo-p-<(4-oxoazetidin-2-yl)acetyl>benzoate 
• 907584-56-9 benzyl m-bromo-p-<1-hydroxy-2-(4-oxoazetidin-2-yl)ethyl>benzoate 
• 907584-57-0 methyl p-<1-acetoxy-2-(4-oxoazetidin-2-yl)ethyl>-m-bromo-benzoate 
• 934388-21-3 4-acetyl-3-bromo-N-pyridin-4-yl-benzamide 
• 1333400-68-2 {1-[2-bromo-4-(pyridine-4-ylcarbamoyl)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 1333400-74-0 {1-[2-bromo-4-(3-fluoro-pyridine-4-ylcarbamoyl)-phenyl]-ethyl}-carbamic acid tert-butyl ester 
• 1333400-77-3 [2'-(1-tert-butoxycarbonylamino-ethyl)-5'-(3-fluoro-pyridin-4-ylcarbamoyl)-biphenyl-3-yloxy]-acetic acid benzyl ester 
• 1333400-65-9 3-bromo-4-(1-tert-butoxycarbonylamino-ethyl)-benzoic acid 

Relevant academic research and scientific papers

PROBES FOR QUANTITATIVE IMAGING OF THIOLS IN VARIOUS ENVIRONMENTS

Embodiments of the present disclosure pertain to methods of detecting a thiol in an environment by exposing the environment to a probe molecule that contains a marker and a thiol responsive group. The thiol responsive group reversibly reacts with the thiol in the environment to form a probe-thiol adduct. This in turn causes a ratiometric change in a spectrometric property of the probe molecule and the probe-thiol adduct, which can then be correlated to the presence of the thiol in the environment. The correlation can occur by quantifying the thiol concentration in the environment. In addition, thiol detection can occur in real-time. Further embodiments of the present disclosure pertain to probe molecules that are utilized for detecting a thiol in an environment. In some embodiments, the probe molecule includes a marker and a thiol responsive group. In some embodiments, the probe molecule also includes an organelle targeting moiety.

KINASE INHIBITORS

The present invention relates to new AGC kinase inhibitors, in particular to compounds of Formula I, II, or III or a stereoisomer, tautomer, racemic, metabolite, pro- or predrug, salt, hydrate, or solvate thereof, I II III wherein X, R1, R2, R3, R31, n, and m have the meaning defined in the claims. In particular, the present invention relates more specifically to ROCK inhibitors, compositions, in particular pharmaceuticals, comprising such inhibitors, and to uses of such inhibitors in the treatment and prophylaxis of disease.

Synthesis of Benzocarbacephem and Benzocarbapenem Derivatives by Copper-promoted Intramolecular Aromatic Substitution

Copper-mediated cyclisation of 4-azetidinones and 4-azetidinones proved to be a route to benzocarbacephem and benzocarbapenem derivatives respectively.The effect of functionalities present in the alkyl part of the ring to be formed was considered with regard to cyclisation efficiency and further chemical modifications.Conversion, into halide, of the diastereoisomeric mixture (4R,6S; 4S,6R; 4R,6R; and 4S,6S) of t-butyl 2-hydroxybenzocarbacephem-4'-carboxylate (14f) afforded either the chloride (17a) as racemic diastereoisomers or the fluoride (17c) as a single racemic diastereoisomer.The corresponding free carboxylic acids (18a, c) were designed as inactivators of beta-lactamases.