113681-64-4

Basic information

• Product Name: 5-(aminosulfonyl)-2-methoxy-N-(1-methyl-4-piperidinyl)benzamide
• Synonyms: 5-(aminosulfonyl)-2-methoxy-N-(1-methyl-4-piperidinyl)benzamide
• CAS NO: 113681-64-4
• Molecular Formula: C14H21N3O4S
• Molecular Weight: 327.39924
• Mol File: 113681-64-4.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 5-(aminosulfonyl)-2-methoxy-N-(1-methyl-4-piperidinyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(aminosulfonyl)-2-methoxy-N-(1-methyl-4-piperidinyl)benzamide(113681-64-4)
• EPA Substance Registry System: 5-(aminosulfonyl)-2-methoxy-N-(1-methyl-4-piperidinyl)benzamide(113681-64-4)

Safety Data

• Hazardous Substances Data: 113681-64-4(Hazardous Substances Data)

Upstream product

• 33045-52-2 methyl 2-methoxy-5-sulfamoyl-benzoate 
• 41838-46-4 4-Amino-1-methylpiperidine 
• 33045-53-3 2-methoxy-5-sulfamoylbenzoic acid ethyl ester 

Relevant articles and documents

POTENTIAL NEUROLEPTICS OF THE ORTHOPRAMIDE SERIES; SYNTHESIS OF N-SUBSTITUTED 5-(AMINOSULFONYL)-2-METHOXYBENZAMIDES

The mixed anhydride of 5-(aminosulfonyl)-2-methoxybenzoic acid (VII) and monoethyl carbonate reacted with benzylamine, 1-methylpiperazine, and 1-benzylpiperazine to give the 5-(aminosulfonyl)-2-methoxybenzamides II, IV, and V.Heating the ethyl ester X with 4-amino-1-methylpiperidine resulted in the amide III.Reaction of 5-(chlorosulfonyl)-2-methoxybenzoyl chloride (XI) with 1-benzylpiperazine afforded 5-(4-benzylpiperazinosulfonyl)-2-methoxybenzoic acid 4-benzylpiperazide (VI).Compounds II-VI are analogues of the antidopaminergic and antiemetic agent sulpiride (I) but only the benzylpiperazides V and VI showed indications of psychotropic activity of the neuroleptic type.