113684-86-9Relevant academic research and scientific papers
Rhodium(III)-catalyzed β-arylation and- alkenylation of α-trifluoromethylacrylic acid
Yoshimoto, Risa,Usuki, Yoshinosuke,Satoh, Tetsuya
, p. 461 - 464 (2019)
The β-arylation and - alkenylation of trifluoromethylacrylic acid with arylboronic acids and alkenes proceed smoothly under rhodium(III) catalysis. The procedures provide useful synthetic routes from readily available building brocks to β-aryl-α-trifluoromethylpropanoic acid and 5, 5, 5-trifluoro-1, 3-butadiene derivatives. Some of the obtained butadienes exhibit strong fluorescence in the solid state.
Preparation of trifluoromethylated dihydrocoumarins, indanones, and arylpropanoic acids by tandem superacidic activation of 2-(Trifluoromethyl) acrylic acid with arenes
Prakash, G. K. Surya,Paknia, Farzaneh,Vaghoo, Habiba,Rasul, Golam,Mathew, Thomas,Olah, George A.
supporting information; experimental part, p. 2219 - 2226 (2010/06/15)
Chemical Reaction Reprentation Indanones and coumarins are important intermediates for the convenient synthesis of many pharmaceutical and biologically active compounds. Fluoroorganics play a vital role in the design of very effective therapeutics due to significant enhancenment in their lipophilicity, bioavailability, and fast uptake by the presence of fluorine in these molecules. Herein, we report an efficient one-pot synthesis of trifluoromethylated arylpropanoic acids, indanones, and dihydrocoumarins using Friedel-Crafts alkylation or tandem Friedel-Crafts alkylation-cycloacylation of arenes/phenols with 2-(trifluoromethyl)acrylic acid under superacidic conditions using trifluoromethanesulfonic acid. The results have been rationalized by the structure energy calculations of the involved reaction intermediates using ab initio theoretical methods.
