113697-03-3

Upstream product

• 495-69-2 Hippuric Acid 
• 591-31-1 3-methoxy-benzaldehyde 
• 98-88-4 benzoyl chloride 
• 108-24-7 acetic anhydride 

Downstream Products

• 564441-56-1 (Z)-2-benzoylamino-N-methyl-3-(3-methoxyphenyl)-2-propenamide 
• 1373927-56-0 S-phenyl (2S,3R)-2-benzamido-3-(3-methoxyphenyl)-3-(phenylthio)propanethioate 
• 1373927-68-4 S-(4-bromophenyl) (2S,3R)-2-benzamido-3-(4-bromophenylthio)-3-(3-methoxyphenyl)propanethioate 
• 1373927-67-3 S-(4-chlorophenyl) (2S,3R)-2-benzamido-3-(4-chlorophenylthio)-3-(3-methoxyphenyl)propanethioate 
• 1798-09-0 m-methoxyphenylacetic acid 
• 65-85-0 benzoic acid 
• 139596-96-6 N-{4-[1-(3-Methoxy-phenyl)-meth-(Z)-ylidene]-5-oxo-2-phenyl-4,5-dihydro-imidazol-1-yl}-isonicotinamide 
• 138973-10-1 1,4-Bis(5'-(3-methoxybenzylidene)-2'-phenyl-4'-imidazolinone-3'-ylamino)phthalazine 
• 1252042-86-6 C₂₄H₁₅Cl₂N₃O₂S 

Relevant academic research and scientific papers

Microwave-Assisted Erlenmeyer Synthesis of Azlactones Catalyzed by MgO/Al2O3 under Solvent-Free Conditions

MgO/Al2O3 catalyzes the synthesis of azlactone derivatives from condensation reaction of aldehydes (or ketones) with hippuric acid and acetic anhydride as a dehydrating agent under microwave irradiation. The low toxicity, low cost, ease of handling, and high activity of MgO/Al2O3 make this procedure particularly attractive. Also, this catalyst can be easily recovered by decant and can be reused for this condensation five times in succession without considerable loss of its catalytic activity.

Novel Molecular Design for Second-Harmonic Generation: Azlactone Derivatives

Novel nonlinear optical materials, azlactone derivatives, have been intensively studied for second-harmonic generation (SHG).Some of these derivatives exhibit large powder SHG efficiency and sufficient transparency in the region of the second-harmonic of Nd:YAG laser radiation (0.532 μm).In particular, the SHG efficiency of 4-(4'-methoxybenzylidene)-2-phenyloxazolin-5-one (MBPO) is found to be about 17 times that of urea.Single crystals of MBPO were prepared by slow evaporation from an acetone solution.These crystals belong to the orthorhombic system with a space group symmetry P212121.The second-order molecular hyperpolarizability (β) value of MBPO was determined to be 24.5 x 1E-30 esu by electric field induced SHG (EFISH) and is nearly equal to the reported β value of 2-methyl-4-nitroaniline (MNA).A calculation of β using the CNDO/S-CI method identifies the HOMO-LUMO transition moment as the dominent contribution to β.Furthermore, the oriented gas model description shows that the β component is aligned to yield the near maximum value possible in an MBPO crystal.The estimated d14 value is 4.61 pm/V, which is on the same order as in potassium titanyl phosphate (KTP).

Bismuth (III) acetate: A new catalyst for preparation of azlactones via the Erlenmeyer synthesis

Bismuth(III) acetate catalyzes the synthesis of azlactones from aromatic aldehydes in moderate to good yields via the Erlenmeyer synthesis. The relatively low toxicity and low cost of bismuth(III) acetate make this procedure particularly attractive.

Synthesis and evaluation of new phenyl acrylamide derivatives as potent non-nucleoside anti-HBV agents

As a continuation of our previous work, a series of new phenyl acrylamide derivatives (4Aa-g, 4Ba-t, 5 and 6a-c) were designed and synthesized as non-nucleoside anti-HBV agents. Among them, compound 4Bs could potently inhibit HBV DNA replication in wild-type and lamivudine (3TC)/entecavir resistant HBV mutant strains with IC50 values of 0.19 and 0.18 μM, respectively. Notably, the selective index value of 4Bs was above 526, indicating the favorable safety profile. Interestingly, unlike nucleoside analogue 3TC, 4Bs could significantly inhibit 3.5 kb pgRNA expression. Molecular docking study revealed that 4Bs could fit well into the dimer-dimer interface of HBV core protein by hydrophobic, π–π and H-bond interactions. Considering the potent anti-HBV activity, low toxicity and diverse anti-HBV mechanism from that of nucleoside anti-HBV agent 3TC, compound 4Bs might be a promising lead to develop novel non-nucleoside anti-HBV therapeutic agents, and warranted further investigation.

Synthesis and herbicidal activity of 4-benzylidene-2-phenyl oxazol-5(4H)-one derivatives using l-proline as catalyst

A simple, efficient and environmentally benign method for the synthesis of 4-benzylidene-2-phenyl oxazol-5(4H)-one derivatives by the reaction of aromatic aldehydes and hippuric acid using acetic anhydride as dehydrating agent and L-proline as catalyst ha

Sulfanilic acid-catalyzed green synthesis of 4-Arylidene-2-phenyl-5(4H)-Oxazolones

This study is focused on the catalytic activity of sulfanilic acid (SA) in the straightforward synthesis of 4-Arylidene-2-phenyl-5(4H)-oxazolones via condensation of aromatic aldehydes, hippuric acid, and acetic anhydride under green experimental conditio

Stereoselective Intermolecular [2 + 2] Cycloadditions of Erlenmeyer-Pl?chl Azlactones Using Visible Light Photoredox Catalysis

The first report of the preparation of symmetric and nonsymmetric diaminotruxinic derivatives through the photoredox [2 + 2] cycloadditions of Erlenmeyer azlactones is described, affording the desired compounds in high regio- and diastereocontrol (only head-to-head coupling). Mechanistic studies by DFT suggest that the reaction proceeds through a neutral photocatalytic pathway.

Synthesis of Erlenmeyer-Pl?chl azlactones promoted by 5-Sulfosalicylic acid

5-Sulfosalicylic acid was found as an efficient catalyst in the synthesis of 4-arylidene-2-phenyl-5(4H)-oxazolones by condensation and cyclodehydration of aromatic aldehydes with hippuric acid and acetic anhydride at room temperature. The catalyst was eas

Microwave-assisted efficient synthesis of azlactones using zeolite NaY as a reusable heterogeneous catalyst

The efficient preparation of azlactones in the presence of zeolite NaY has been reported. This heterogeneous catalyst was used for efficient synthesis of azlactone derivatives with Ac2O as a condensing agent under microwave irradiation and solvent-free co

Synthesis and insecticidal evaluation of tetrahydroimidazo[1,2-a]pyridin-5(1H)-one derivatives

A series of novel tetrahydroimidazo[1,2-a]pyridine-5(1H)-one derivatives containing a electronegative pharmacophore (=CNO2) were synthesized via practical aza-ene reaction and characterized by 1H NMR, 13C NMR, 19F NMR and HRMS. Preliminary bioassays showed that some of the target compounds exhibited good insecticidal activity against brown planthopper (Nilaparvata lugens) and cowpea aphids (Aphis craccivora) at 500 mg L-1. Among them, compound 11h was active against brown planthopper at 100 mg L-1. The insecticidal activities varied significantly depending on the types and patterns of the substituents, which provided guidance for further investigation on structure modifications.