113700-23-5

Basic information

• Product Name: 5-[(4-Fluorophenyl)methyl]-3,4-dihydro-2H-pyrrole
• Synonyms: 5-[(4-Fluorophenyl)methyl]-3,4-dihydro-2H-pyrrole;5-(4-Fluorobenzyl)-3,4-dihydro-2H-pyrrole;5-(4-fluorophenyl)-3,4-dihydro-2H-pyrrole
• CAS NO: 113700-23-5
• Molecular Formula: C₁₁H₁₂FN
• Molecular Weight: 177.22
• Mol File: 113700-23-5.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 5-[(4-Fluorophenyl)methyl]-3,4-dihydro-2H-pyrrole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-[(4-Fluorophenyl)methyl]-3,4-dihydro-2H-pyrrole(113700-23-5)
• EPA Substance Registry System: 5-[(4-Fluorophenyl)methyl]-3,4-dihydro-2H-pyrrole(113700-23-5)

Safety Data

• Hazardous Substances Data: 113700-23-5(Hazardous Substances Data)

Usage

General Description

5-[(4-Fluorophenyl)methyl]-3,4-dihydro-2H-pyrrole, also known as FMP, is a chemical compound with the molecular formula C12H13FN. It is a derivative of pyrrole, a heterocyclic compound containing a five-membered ring with one nitrogen atom. FMP is a colorless liquid with a molecular weight of 189.24 g/mol. 5-[(4-Fluorophenyl)methyl]-3,4-dihydro-2H-pyrrole is used in pharmaceutical research and is being investigated for its potential medicinal properties, particularly in the field of neurological and psychiatric disorders. Its structure contains a fluorophenylmethyl group, which may impart unique pharmacological properties that are being explored for potential therapeutic applications.

Upstream product

• 34837-84-8 4-fluorobenzeneacetic acid methyl ester 
• 405-50-5 p-Fluorophenylacetic acid 
• 628-20-6 4-Chlorobutyronitrile 
• 459-46-1 4-Fluorobenzyl bromide 

Downstream Products

• 350017-04-8 2-(4-fluorobenzyl)pyrrolidine 

Relevant articles and documents

A 2 - (4 - fluorobenzyl) pyrrolidine preparation method (by machine translation)

The invention discloses a 2 - (4 - fluorobenzyl) pyrrolidine of preparation method, to the fluorophenyl acetic acid as the starting material, through esterification, coupling, open-loop, closed-loop, reduction to obtain the target product, the compound is an important medical intermediates. (by machine translation)

Cyclooxygenase-1/2 (COX-1/COX-2) and 5-lipoxygenase (5-LOX) inhibitors of the 6,7-diaryl-2,3-1H-dihydropyrrolizine type

A series of 6,7-diaryl-2,3-1H-dihydropyrrolizines was prepared as COX-1/COX-2 and 5-LOX inhibitors. The inhibition of COX-1 was evaluated using intact bovine platelets as the enzyme source, whereas LPS-stimulated human monocytes served as the enzyme source for inducible COX-2. The determination of arachidonic metabolites was performed by HPLC for COX-1 and RIA for COX-2. The balance between COX-1/COX-2 and 5-LOX inhibition can be shifted by modifying the substitution pattern of the phenyl moiety at the 6- and 7-position of the pyrrolizine nucleus. Structure-activity relationships are discussed.