113709-36-7Relevant academic research and scientific papers
LITHIUM N-BENZYLTRIMETHYLSILYLAMIDE (LSA): A NEW REAGENT FOR CONJUGATE ADDITION - ENOLATE TRAPPING REACTIONS
Asao, Naoki,Uyehara, Tadao,Yamamoto, Yoshinori
, p. 4173 - 4180 (2007/10/02)
Lithium N-benzyltrimethylsilylamide (LSA) adds to crotonates in a 1,4-manner, though the reaction of ordinary lithium amides with α,β-unsaturated carbonyl compounds is accompanied with a 1,2-addition and hydrogen abstraction at the γ-position.The conjugat
Stereoselective α-Alkylation of α,β-Unsaturated Esters Utilizing Conjugate Addition of Nitrogen Nucleophiles (R2NLi)
Uyehara, Tadao,Asao, Naoki,Yamamoto, Yoshinori
, p. 1410 - 1411 (2007/10/02)
Treatment of α,β-unsaturated esters (1) with lithium amides i2 and LiN(CH2Ph)SiMe3> followed by alkylation and elimination of the amino groups produced trisubstituted enoates (2) with high stereoselectivity.
