113726-75-3Relevant academic research and scientific papers
Synthesis of Oxaziridinylquinones and Oxaziridinylazines as Potential Antitumor Agents
Mlochowski, Jacek,Kubicz, Elzbieta,Kloc, Krystian,Mordarski, Marian,Peczynska, Wanda,Syper, Ludwik
, p. 455 - 464 (2007/10/02)
1,4-Benzoquinones, 1,4-naphthoquinones, as well as pyridines and quinolines having 2-alkyloxaziridinyl substituents were synthesized.The method involves formation of aldimines and their oxidation to oxaziridines. 1,4-Dimethoxyarenes bearing oxaziridinyl substituents were converted into the corresponding quinones with silver(II) dipicolinate.Some of the oxaziridinylquinones and -azines exhibit activity against KB cells, and the structure-activity relationship is discussed in terms of the current theory of biologically activated alkylating agents.
Synthesis of 2-Alkyl-3-aryloxaziridines
Kloc, Krystian,Kubicz, Elzbieta,Mlochowski, Jacek,Syper, Ludwik
, p. 1084 - 1087 (2007/10/02)
A convenient method for the synthesis of 2-alkyl-3-aryloxaziridines 1 based on the formation of stable azomethines and their oxidation with m-chloroperoxybenzoic acid is reported.The scope and limitation of the method proposed is illustrated with numerous
