86489-95-4

Upstream product

• 40870-58-4 1-chloromethyl-2,5-dimethoxy-3,4-dimethyl-benzene 
• 608-43-5 2,3-dimethyl-1,4-dihydroxybenzene 
• 103323-61-1 1-bromo-2,5-dimethoxy-3,4-dimethylbenzene 
• 68-12-2 N,N-dimethyl-formamide 
• 39021-83-5 3,6-dimethoxy-o-xylene 
• 100-97-0 hexamethylenetetramine 
• 4885-02-3 Dichloromethyl methyl ether 
• 86489-88-5 1-bromomethyl-2,5-dimethoxy-3,4-dimethylbenzene 

Downstream Products

• 111023-20-2 1,4-Dimethoxy-2,3-dimethyl-5-(2-methyl-propenyl)-benzene 
• 86498-87-5 1,4-dimethoxy-2,3-dimethyl-5-oxiranylbenzene 
• 74422-74-5 2,5-dimethoxy-3,4-dimethyl-6-nitrobenzaldehyde 
• 855286-83-8 5-bromo-6-hydroxy-7,8-dimethyl-2-oxo-2H-chromene-3-carboxylic acid 
• 854661-82-8 2-bromo-3,6-dihydroxy-4,5-dimethyl-benzaldehyde 
• 327175-13-3 (2,5-dimethoxy-3,4-dimethyl-phenyl)-acetonitrile 
• 66890-58-2 2,5-dimethoxy-3,4-dimethylphenol 
• 54-28-4 gamma-tocopherol 

Relevant academic research and scientific papers

PREPARATION AND USES OF REACTIVE OXYGEN SPECIES SCAVENGER DERIVATIVES

Compounds of Formula (I) a or (I) b: including certain quinone derivatives, and the corresponding pharmaceutical compositions, which may serve to modulate ferroptosis in a subject. Also disclosed herein are the preparations of these compounds and pharmaceutical compositions and their potential uses in the manufacture of a medicament in reducing reactive oxygen species (ROS) in a cell and for preventing, treating, ameliorating certain related disorder or a disease.

Total synthesis of (R, R, R)-γ-tocopherol through cu-catalyzed asymmetric 1,2-addition

Based on the asymmetric copper-catalyzed 1,2-addition of Grignard reagents to ketones, (R, R, R)-γ-tocopherol has been synthesized in 36% yield over 12 steps (longest linear sequence). The chiral center in the chroman ring was constructed with 73% ee by the 1,2-addition of a phytol-derived Grignard reagent to an a-bromo enone prepared from 2,3-dimethylquinone.

Enzymatic substrates derived from phenoxazinone and their use as developer in detection of microorganisms with peptidase activity

Novel enzymatic substrates of the general formula below: reaction media containing the same and their use for detecting and/or identifying and/or quantifying microorganisms expressing at least one peptidase activity.

Synthesis and testing of chromogenic phenoxazinone substrates for β-alanyl aminopeptidase

Novel 7-N-(β-alanyl)aminophenoxazin-3-one salts 27a-d have been synthesized and tested as chromogenic substrates for β-alanyl aminopeptidase, which is present in Pseudomonas aeruginosa, the most common respiratory pathogen in patients with cystic fibrosis. The biological results show that 7-N-(β-alanyl)amino-1-pentylphenoxazin-3-one trifluoroacetate salt 27a is a chromogenic substrate for this bacterium, with a low degree of diffusion in nutrient media for growing bacterial cultures and a bright red colour, making it easily distinguishable from the agar background. This journal is The Royal Society of Chemistry.

Treatment of mitochondrial diseases

The invention relates the method of treatment or amelioration of mitochondrial disorders such as Alzheimer's disease, Parkinson's disease, Friedreich's ataxia (FRDA), cerebellar ataxias, Leber's hereditary optic neuropathy (LHON), mitochondrial myopathy,

DIHYDROBENZOFURAN DERIVATIVES, PROCESS FOR THE PREPARATION THEREOF AND AGENTS

A compound represented by the formula (I): or a salt thereof exhibits excellent inhibitory activity of lipid peroxidation and is useful as an agent for inhibiting lipoperoxide production, wherein A ring denotes a non-aromatic 5- to 7-membered nitrogen-con

SYNTHESIS OF OXIRANYLQUIONOES AS NEW POTENTIAL BIOREDUCTIVE ALKYLATING AGENTS

1,4-Benzoquinones and 1,4-naphtoquinones carrying oxiranyl substituents have been synthesized as potential bioreductive alkylating agents.The method presented here involves the syntheses of 1,4-dimethoxybenzaldehydes or 1,4-dimethoxynaphtaldehydes, and co