113727-10-9

Upstream product

• 16652-75-8 L-isoleucine benzyl ester tosylate 
• 87215-41-6 N-(t-butoxycarbonyl)prolylprolylglycine benzyl ester 
• 90315-54-1 N-(tert-Butyloxycarbonyl)glycyl-L-isoleucin-benzylester 

Downstream Products

• 90315-56-3 (S)-2-((S)-2-{[((1S,2S)-1-Benzyloxycarbonyl-2-methyl-butylcarbamoyl)-methyl]-carbamoyl}-pyrrolidine-1-carbonyl)-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 113727-11-0 N-(Fluorenylmethoxycarbonyl)-3-O-tert-butyl-L-seryl-glycyl-L-isoleucin-benzylester 
• 113727-08-5 N-(Benzyloxycarbonyl)-L-alanyl-3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-L-seryl-glycyl-L-isoleucin-benzylester 
• 113747-55-0 N-(Benzyloxycarbonyl)-L-alanyl-3-O-(2,3,4-O-acetyl-β-D-xylopyranosyl)-L-seryl-glycyl-L-isoleucin-benzylester 
• 113727-13-2 N-(Benzyloxycarbonyl)-L-alanyl-3-O-tert-butyl-L-seryl-glycyl-L-isoleucin-benzylester 
• 113727-07-4 N-(Benzyloxycarbonyl)-L-alanyl-L-seryl-glycyl-L-isoleucin-benzylester 
• 113727-12-1 (2S,3S)-2-[2-((S)-2-Amino-3-tert-butoxy-propionylamino)-acetylamino]-3-methyl-pentanoic acid benzyl ester 

Relevant academic research and scientific papers

STUDIES OF BITTER PEPTIDES FROM CASEIN HYDROLYZATE - VI. SYNTHESES AND BITTER TASTE OF BPIc (VAL-TYR-PRO-PHE-PRO-PRO-GLY-ILE-ASN-HIS) AND ITS ANALOGS AND FRAGMENTS.

In order to investigate the relationship between chemical structure and bitter taste, the bitter peptide BPIc (Val-Tyr-Pro-Phe-Pro-Pro-Gly-Ile-Asn-His) isolated from casein hydrolyzate by Minamiura et al. and its analogs and fragments were synthesized. BPIc, whose threshold value of bitter taste was 0. 05 mm, was found to be one of the most bitter compounds, like quinine and phenylthiourea. However, left bracket Gly**5**,**6 right bracket - and left bracket Gly**9**,**1**0 right bracket -BPIc, and N-terminal octa- and heptapeptide fragments of BPIc possessed much weaker bitterness than BPIc. The results suggested that 5,6-proline and the basic nature of C-terminal are necessary for the strong bitterness exhibited by BPIc.

Synthesis of L-Alanyl-3-O-(β-D-xylopyranosyl)-L-seryl-glycyl-L-isoleucine. Direct Glycosydation of Peptides

Glycosidation of the tetrapeptide 8 either with 1,2,3,4-tetra-O-acetyl-β-D-xylopyranose (1) under catalysis of trimethylsilyl triflate or with ethyl 2,3,4-tri-O-benzoyl-1-thio-β-D-xylopyranoside (4) using DMTST as promotor, leads to the O-glycopeptides 10 and 9.Deblocking of 10 affords the glycopeptide L-Ala-3-O-(β-D-Xylp)-L-Ser-Gly-L-Ile (11), which represents the N-terminal amino acid sequence 3 to 6 of the protein core of a proteodermantan sulfate.