473-16-5

Basic information

• Product Name: 2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]propan-2-ol
• Synonyms: (-)-a-Eudesmol; .alpha.-Eudesmol; 1,2b,3,4,4a,5,6,8ab-octahydro-a,a,4aa,8-tetramethyl-2-naphthalenemethanol; 2-[(2R,4aR,8aR)-4a,8-Dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]propan-2-ol; 2-naphthalenemethanol, 1,2,3,4,4a,5,6,8a-octahydro-alpha,alpha,4a,8-tetramethyl-, (2R,4aR,8aR)-; 473-16-5; a-Selinenol; Eudesm-3-en-11-ol
• CAS NO: 473-16-5
• Molecular Formula: C₁₅H₂₆O
• Molecular Weight: 222.3663
• Mol File: 473-16-5.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 301.1°C at 760 mmHg
• Flash Point: 108.3°C
• Density: 0.959g/cm³
• Vapor Pressure: 0.000105mmHg at 25°C
• Refractive Index: 1.5
• CAS DataBase Reference: 2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]propan-2-ol(473-16-5)
• EPA Substance Registry System: 2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]propan-2-ol(473-16-5)

Safety Data

• Hazardous Substances Data: 473-16-5(Hazardous Substances Data)

Usage

General Description

2-[(2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl]propan-2-ol, also known as Octahydro-1,2,3,4,4a,5,6,8a-octahydronaphthalen-2-yl)propan-2-ol, is a synthetic compound that belongs to the class of organic compounds known as naphthalenes. This chemical compound is commonly used as an intermediate for the synthesis of other compounds. It is a colorless liquid with a mild, aromatic odor and is insoluble in water but soluble in most organic solvents. It is important to handle and store this chemical compound with care, as it may pose health and environmental hazards if not properly managed.

Upstream product

• 157241-50-4 (+)-hedycaryol 
• 917-54-4 methyllithium 
• 78719-76-3 1-((2R,4aR,8aR)-4a,8-Dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-ethanone 
• 28399-17-9 (+)-Eudesma-3,11⁽¹³⁾-dien-12-oic acid 
• 188174-77-8 2-((3E,8E)-4,8-Dimethyl-cyclodeca-3,8-dienyl)-propan-2-ol 
• 83093-43-0 (1S,4aS,7R,8aS)-7-(1,2-Dihydroxy-1-methyl-ethyl)-1,4a-dimethyl-octahydro-naphthalen-2-one 
• 92803-54-8 C₂₂H₃₄N₂O₄S 
• 80322-01-6 2-((2R,4aR,8aR)-4a,8-Dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-propane-1,2-diol 
• 92803-57-1 Toluene-4-sulfonic acid 2-((2R,4aR,8aR)-4a,8-dimethyl-1,2,3,4,4a,5,6,8a-octahydro-naphthalen-2-yl)-2-hydroxy-propyl ester 
• 55170-74-6 5-methylhex-5-enoic acid 
• 1188293-39-1 15-bromoeudesmol 
• 253864-06-1 Trifluoro-methanesulfonic acid (4aR,7R,8aR)-4a-methyl-7-(1-methyl-1-triethylsilanyloxy-ethyl)-3,4,4a,5,6,7,8,8a-octahydro-naphthalen-1-yl ester 
• 253864-05-0 (4aR,7R,8aR)-4a-Methyl-7-(1-methyl-1-triethylsilanyloxy-ethyl)-octahydro-naphthalen-1-one 
• 473-15-4 beta-eudesmol 

Downstream Products

• 473-10-9 carissone 
• 113773-90-3 (+)-chrysanthemol 
• 473-13-2 (-)-α-selinene 
• 107038-42-6 β-eudesmyl 3,5-dinitrobenzoate 
• 6770-16-7 dihydroeudesmol 

Relevant articles and documents

Unified Approach to ent -Eudesmane-Type Terpenoid Synthesis: Total Synthesis of Sinupol and Eutyscoparin A

ent-Eudesmane-type terpenoids constitute a large class of natural products derived from plants, animals, and bacteria. We describe a synthetic approach to two ent-eudesmane-type terpenoids, sinupol and eutyscoparin A, that relies on a key π-facial-and endo/exoselective intramolecular Diels Alder reaction to set the C-5 C-10 stereotriads. Further key transformations of trans-fused decalin include conversion to methyl ketone via a versatile thioester intermediate and appropriate functionalization toward target compounds.

Ilicic Acid as a Natural Quiron for the Efficient Preparation of Bioactive α- and β-Eudesmol

An efficient procedure for the isolation of the sesquiterpene ilicic acid (3) on a multigram scale of extracts obtained from aerial parts of Inula viscosa (Asteraceae) was developed. Acid 3 is an appropriate starting material for short, enantio-specific s

Stereoselective total synthesis of (-)-α-eudesmol, a P/Q-type calcium channel blocker

Practical and stereoselective total synthesis of (-)-αeudesmol 1, a P/Q-type calcium channel blocker, has been achieved with the key step being a cyclopropane ring opening accompanying introduction of a hydroxyl group. (+)-Carissone is used as a key intermediate.