113826-06-5

Basic information

• Product Name: (2R)-(-)-Glycidyl tosylate
• Synonyms: (2R)-GLYCIDYL TOLUENESULFONATE;(2R)-(-)-GLYCIDYL TOSYLATE;(2R)-OXIRAN-2-YLMETHYL 4-METHYLBENZENESULPHONATE;(2R)-(-)-TOLUENE-4-SULFONIC ACID 2,3-EPOXYPROPYL ESTER;LABOTEST-BB LT00440878;OXIRANEMETHANOL, 4-METHYLBENZENESULFONATE, (2R)-;(S)-Oxiranemethanol 4-methylbenzenesulfonate;(R)-(-)-OXIRANE-2-METHANOL 4-TOLUENESULFONATE
• CAS NO: 113826-06-5
• Molecular Formula: C₁₀H₁₂O₄S
• Molecular Weight: 228.26
• EINECS: 205-970-0
• Product Categories: chiral;API intermediates;Chiral Compound;Ring Systems;Aromatics;Carbohydrates & Derivatives;Sulfur & Selenium Compounds
• Mol File: 113826-06-5.mol
• Article Data: 14

Chemical Properties

• Melting Point: 46-49 °C(lit.)
• Boiling Point: 340.07°C (rough estimate)
• Flash Point: >230 °F
• Appearance: yellow to orange/powder
• Density: 1.3749 (rough estimate)
• Vapor Pressure: 2.35E-05mmHg at 25°C
• Refractive Index: 1.5400 (estimate)
• Storage Temp.: 2-8°C
• Solubility: dioxane: 50 mg/mL, clear
• Water Solubility: decomposes
• BRN: 3592142
• CAS DataBase Reference: (2R)-(-)-Glycidyl tosylate(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-(-)-Glycidyl tosylate(113826-06-5)
• EPA Substance Registry System: (2R)-(-)-Glycidyl tosylate(113826-06-5)

Safety Data

• Hazard Codes: Xn,N,T
• Statements: 45-41-43-51/53-68
• Safety Statements: 61-45-36/37/39-26-53
• RIDADR: UN 3077 9/PG 3
• WGK Germany: 3
• RTECS: RR0510000
• F: 3-10-21
• HazardClass: 9
• Hazardous Substances Data: 113826-06-5(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

Uses

Different sources of media describe the Uses of 113826-06-5 differently. You can refer to the following data:
1. Protected Glycidol, (2R)-(-)-Glycidyl tosylate is used as an intermediate in the preparation of neurochemicals.
2. (2R)-(-)-Glycidyl Tosylate is a protected glycidol used as an intermediate in the preparation of neurochemicals.
3. (2R)-(-)-Glycidyl tosylate may be used to prepare:1-O-hexadecyl-sn-glycerol 3-O-p-toluenesulfonate by reacting with 1-hexadecanol in the presence of boron trifluoride etherate. 4-Oxiranylmethoxy-(1H)-indole by reacting with 4-hydroxyindole in the presence of sodium hydride.[18F]Epifluorohydin, an intermediate for preparing of [18F]fluoromisonidazole.It can also be used as a starting material in the synthesis of 1,2-diacyl-sn-3-glycerophosphocholines.

InChI:InChI=1/C10H12O4S/c1-8-2-4-10(5-3-8)15(11,12)14-7-9-6-13-9/h2-5,9H,6-7H2,1H3

Upstream product

• 107-18-6 allyl alcohol 
• 98-59-9 p-toluenesulfonyl chloride 
• 118712-54-2 glycidyl p-toluenesulfonate 
• 60456-23-7 (S)-oxiranemethanol 
• 556-52-5 oxiranyl-methanol 

Downstream Products

• 69500-53-4 4-{4-[(2S)-oxiran-2-ylmethoxy]-1,2,5-thiadiazol-3-yl}morpholine 
• 741719-53-9 4-{4-[(2R)-oxiran-2-ylmethoxy]-1,2,5-thiadiazol-3-yl}morpholine 
• 99291-25-5 levodropropizine 
• 120019-37-6 3-hexadecyloxy-2R-hydroxypropyl 1-para-toluenesulphonate 
• 119944-30-8 3‐hexadecyloxy‐2R‐hydroxyl propyl‐1‐p‐toluene sulphonate 
• 142350-40-1 1-O-(5'-carbomethoxypentyl)-sn-glyceryl-3-tosylate 
• 152467-60-2 Toluene-4-sulfonic acid (R)-3-(16-chloro-hexadecyloxy)-2-hydroxy-propyl ester 
• 146838-97-3 (R,S)-1-(1-Naphthyloxy)-2-hydroxy-3-N-(1-phenylethylamino)propane hydrochloride 
• 146838-99-5 (R,R)-(+)-1-(1-Naphthyloxy)-2-hydroxy-3-N-(1-phenylethylamino)propane hydrochloride 
• 136404-80-3 (S)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane 
• 136404-79-0 (R)-1-azido-2-trimethylsilyloxy-3-tosyloxypropane 
• 118629-68-8 (R)-1,2-epoxy-3-(2'-cyclopentylphenoxy)propane 
• 154531-76-7 (S)-1,2-epoxy-3-(2'-cyclopentylphenoxy)propane 
• 119702-02-2 (R)-2-(2-Benzyloxy-phenoxymethyl)-oxirane 

Relevant articles and documents

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The invention provides a method for simply and selectively manufacturing an optically active cyclic ether aryl sulfonic acid ester with an inexpensively obtained racemate as the raw material. The method for manufacturing the cyclic ether aryl sulfonic acid ester comprises the steps of with the existence of optically active bisoxazoline ligand, lewis acid compound, alkali and organic solvent, aryl sulfonyl halide and hydroxymethyl cyclic ether are subjected to the racemate reaction to obtain an optically active cyclic ether aryl sulfonic acid ester. Preferably glycidyl or 2-hydroxymethyl tetrahydrofuran is adopted as the above hydroxymethyl cyclic ether.