16495-04-8

Usage

Uses

Used in Organic Synthesis:
(S)-(+)-1-Benzyloxy-3-(p-tosyloxy)-2-propanol is used as a reagent in organic reactions for the formation of carbon-carbon and carbon-oxygen bonds, which are fundamental in constructing complex organic molecules.
Used in Pharmaceutical Synthesis:
In the pharmaceutical industry, (S)-(+)-1-benzyloxy-3-(p-tosyloxy)-2-propanol is employed as a key intermediate in the synthesis of various drugs, leveraging its ability to form essential chemical bonds and contribute to the development of new medicinal compounds.
Used in Agrochemical Production:
(S)-(+)-1-Benzyloxy-3-(p-tosyloxy)-2-propanol also finds application in the agrochemical sector, where it serves as a precursor in the synthesis of pesticides and other agricultural chemicals, enhancing crop protection and yield.
Used in the Production of Fine Chemicals:
(S)-(+)-1-BENZYLOXY-3-(P-TOSYLOXY)-2-PROPANOL is utilized in the synthesis of fine chemicals, which are high-purity chemicals used in various industries such as fragrances, flavors, dyes, and more, due to its ability to form specific functional groups required in these applications.
Overall, (S)-(+)-1-benzyloxy-3-(p-tosyloxy)-2-propanol is a multifaceted chemical with applications spanning across different industries, highlighting its importance in modern chemical production and research.

InChI:InChI=1/C17H20O5S/c1-14-7-9-17(10-8-14)23(19,20)22-13-16(18)12-21-11-15-5-3-2-4-6-15/h2-10,16,18H,11-13H2,1H3/t16-/m0/s1

Upstream product

• 70987-78-9 (S)-Glycidyl tosylate 
• 100-51-6 benzyl alcohol 
• 113826-06-5 (R)-glycidyl tosylate 
• 16495-03-7 (S)-4-(benzyloxymethyl)-2,2-dimethyl-1,3-dioxolane 
• 4726-96-9 O-Benzyl-L-serine 
• 50765-70-3 (S)-1-tosyloxy-2,3-propanediol 
• 100-44-7 benzyl chloride 
• 56552-80-8 (R)-3-benzyloxy-1,2-propanediol 
• 98-59-9 p-toluenesulfonyl chloride 
• 127744-28-9 (S)-methyl 3-(benzyloxy)-2-hydroxypropanoate 
• 130111-08-9 (S)-3-(benzyloxy)-2-hydroxypropanoic acid 

Downstream Products

• 50765-70-3 (S)-1-tosyloxy-2,3-propanediol 
• 14618-80-5 (R)-benzyl glycidol 
• 119835-76-6 S-(-)-1-benzyloxy-3-phtalimidopropanol 
• 41274-09-3 D-3-Tosylglycerol 
• 83526-59-4 2-O-Acetyl-3-O-benzyl-1-O-octadecyl-sn-glycerin 
• 83537-02-4 3-O-Benzyl-2-O-formyl-1-O-octadecyl-sn-glycerin 
• 83167-58-2 3-O-Benzyl-2-O-methyl-1-O-octadecyl-sn-glycerin 
• 83167-57-1 3-O-Benzyl-1-O-octadecyl-sn-glycerol 
• 1447919-67-6 (S)-toluene-4-sulfonic acid-3-benzyloxy-2-(phenoxycarbonyloxy)-propyl ester 
• 1447919-69-8 acetic acid-1-benzyloxymethyl-2-{[(R)-(3-oxo-morpholin-4-yl)-phenyl]-chlorocarbonyl-amino} ethyl ester 
• 1447919-68-7 acetic acid-1-benzyloxymethyl-2-[(R)-4-(3-oxo-morpholin-4-yl)phenylamino]-ethylester 
• 1117893-59-0 4-(4-((R)-5-benzyloxymethyl-2-oxo-oxazolidin-3-yl)phenyl)morpholin-3-one 

Relevant academic research and scientific papers

TAU IMAGING PROBE

An object of the present invention is to provide a compound represented by formula (I) which is highly specific to tau and can image tau with satisfactory sensitivity, and also has high brain transition, low or non-recognized bone-seeking properties and low or undetected toxicity.

Preparation of optically active 1,2-diol monotosylates by enzymatic hydrolysis

An easy preparation of optically active 1,2-diol monotosylate derivatives by enzymatic hydrolysis is disclosed. Lipase PS (Burkholderia cepacia) catalyzes the hydrolysis of racemic 2-acetoxyhexyl tosylate with excellent enantioselectivity to afford the corresponding optically active compounds. In this reaction, a unique temperature effect is observed. After optimizing the reaction conditions, this procedure is widely applicable to the practical preparation of both enantiomers of various optically active compounds with high ee. Georg Thieme Verlag Stuttgart.

Preparation of optically active 1-O-alkyl-3-O-arylsulfonyl-sn-grycerol derivatives: Substrate engineering in enzyme-mediated enantioselective hydrolysis

Lipase PS catalyzes the enantioselective hydrolysis of various 2-acetyl compounds of the 1-O-alkyl-3-O-arylsulfonyl-sn-glycerol derivatives to afford the corresponding optically active compounds. Changing the structure of the 1-O-alkyl and 3-O-arylsulfonyl groups affects both the reactivity and enantioselectivity. Finally, the E value of the reaction for 2-acetyl-3-O-3,5-dimethylbenzenesulfonyl-1-O-4-methoxybenzyl-sn-glycerol is greater than 200. Georg Thieme Verlag Stuttgart.

A pre-RNA candidate revisited: Both enantiomers of flexible nucleoside triphosphates are DNA polymerase substrates

One of the earliest proposed pre-RNA candidates is the flexible nucleic acid (FNA) structure based on the mixed acetal aminal of formyl glycerol. FNA achieves dramatic stereochemical simplification by formally deleting the 2′-CHOH group of RNA, thereby re

Scavenger assisted combinatorial process for preparing libraries of tertiary amine compounds

This invention relates to a novel solution phase process for the preparation of tertiary amine combinatorial libraries. These libraries have utility for drug discovery and are used to form wellplate components of novel assay kits.

Stereoselective total synthesis of (2R,2′S,3Z)-1-O-(2-methoxyhexadecenyl) glycerol and (2R,2′S)-1-(2′-methoxyhexadecyl)glycerol-potential antitumour compounds from Shark liver oil

A simple and high yielding route for the stereoselective synthesis of alkyl glycerol ethers namely (2R,2′S,3Z)-1-O-(2-methoxyhexadecenyl)glycerol 1 and (2R,2′S)-1-(2′-methoxyhexadecyl) glycerol 2, isolated form Shark liver oil is reported. The key reaction involves the Wittig olefination of the chiral aldehyde 12 with the ylide generated from tridecyl triphenyl phosphonium bromide results in the formation of compound 13, a precursor for the title compounds 1 and 2.

SYNTHESIS OF(2R) AND (2S)-BENZYL-2,3-EPOXYPROPYL ETHER FROM A COMMON PRECURSOR: O-BENZYL-L-SERINE

The (2R) and (2S)-benzyl-epoxypropyl ether are obtained from commercially available O-benzyl-serine, via nitrosation and Mitsunobu reactions to afford the chiral precursors of the above epoxy ethers.

A TWO-STEP SYNTHESIS OF (R)- AND (S)-BENZYLGLYCIDYL ETHER

Ring opening of (R)- and (S)-glycidyl tosylates with benzyl alcohol, followed by treatment with K2CO3/MeOH gave (S)-(+)- and (R)-(-)-benzylglycidyl ether in 90percent overall yield.