113917-66-1Relevant articles and documents
SYNTHESIS OF (25R)-CHOLESTEROL AND 1H N.M.R. AND H.P.L.C. RESOLUTION OF (25R)- AND (25S)-26-HYDROXYCHOLESTEROL
Uomori, Atsuko,Seo, Shujiro,Sato, Tomohiro,Yoshimura, Yohko,Takeda, Ken'ichi
, p. 1713 - 1718 (2007/10/02)
Yamogenin acetate (1) was isolated from crude diosgenin acetate and converted into (25S)-26-hydroxycholesterol (6a).The absolute configuration at C-25 of (6a) was determined by X-ray crystallography. (25R)-Cholesterol (10) was prepared by reduction of the 26-tosyloxy group by LiAl(2)H4.Reverse-phase h.p.l.c. resolution without derivatization was developed for the diastereoisomers, (25R)- and (25S)-26-hydroxycholesterol.The (+)- or (-)-MTPA esters of these diastereoisomers showed distinctive 1H n.m.r. signals for 26-H.