113975-69-2

Upstream product

• 113975-70-5 methyl α-(phenylmethyl)indole-3-acetate 
• 113996-90-0 methyl 2,3-dihydro-3-hydroxy-2-oxo-α-(phenylmethyl)-1H-indole-3-acetate 
• 87-51-4 indole-3-acetic acid 
• 1912-33-0 Indole-3-acetic acid methyl ester 
• 103-25-3 3-phenylpropanoic acid methyl ester 
• 91-56-5 indole-2,3-dione 
• 57115-38-5 α-(phenylmethyl)indole-3-acetic acid 
• 100-44-7 benzyl chloride 
• 526-55-6 2-(3-indole)-ethanol 
• 100-51-6 benzyl alcohol 

Downstream Products

• 113975-74-9 trans-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano<3,4-b>indole-1-acetic acid 
• 114030-44-3 (1S,4R)-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)-pyrano[3,4-B]indole-1-acetic acid 
• 114030-45-4 (-)-pemedolac 
• 113975-73-8 cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano<3,4-b>indole-1-acetic acid methyl ester 
• 113975-83-0 trans-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyrano<3,4-b>indole-1-acetic acid methyl ester 

Relevant academic research and scientific papers

Iron-Catalyzed β-Alkylation of Alcohols

β-Branched alkylated alcohols have been prepared in good yields using a double-hydrogen autotransfer strategy in the presence of our diaminocyclopentadienone iron tricarbonyl complex Fe1. The alkylation of some 2-arylethanol derivatives was successfully addressed with benzylic alcohols and methanol as alkylating reagents under mild conditions. Deuterium labeling experiments suggested that both alcohols (2-arylethanol and either methanol or benzyl alcohol) served as hydrogen donors in this cascade process.

Synthesis and Analgesic Activity of Pemedolac (cis-1-Ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyranoindole-1-acetic Acid)

The synthesis of cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyranoindole-1-acetic acid, pemedolac (USAN), is described.This compound has been found to be a potent analgesic agent in primary screening.Pemedolac has been resolved and the active (+)-enantiomer assigned a 1S,4R absolute configuration on the basis of a crystallographic analysis of its (S)-(-)-borneol ester.