57115-38-5Relevant articles and documents
Synthesis and Analgesic Activity of Pemedolac (cis-1-Ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyranoindole-1-acetic Acid)
Katz, Alan H.,Demerson, Christopher A.,Shaw, Chia-Cheng,Asselin, Andre A.,Humber, Leslie G.,et al.
, p. 1244 - 1250 (1988)
The synthesis of cis-1-ethyl-1,3,4,9-tetrahydro-4-(phenylmethyl)pyranoindole-1-acetic acid, pemedolac (USAN), is described.This compound has been found to be a potent analgesic agent in primary screening.Pemedolac has been resolved and the active (+)-enantiomer assigned a 1S,4R absolute configuration on the basis of a crystallographic analysis of its (S)-(-)-borneol ester.
Production of substituted 1,3,4,9-tetrahydropyrano(3,4-b)indole-1-acetic acids
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, (2008/06/13)
Process for the production of substituted 1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acids having useful analgesic and anti-inflammatory activity.