1140495-84-6

Basic information

• Product Name: 1-Pyrrolidinecarboxylic acid, 2-[[[(4-chlorophenyl)Methyl]aMino]carbonyl]-, 1,1-diMethylethyl ester, (2R)-
• Synonyms: 1-Pyrrolidinecarboxylic acid, 2-[[[(4-chlorophenyl)Methyl]aMino]carbonyl]-, 1,1-diMethylethyl ester, (2R)-;(R)-tert-Butyl 2-(4-chlorobenzylcarbamoyl)pyrrolidine-1-carboxylate
• CAS NO: 1140495-84-6
• Molecular Formula: C₁₇H₂₃ClN₂O₃
• Molecular Weight: 338.82912
• Mol File: 1140495-84-6.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 1-Pyrrolidinecarboxylic acid, 2-[[[(4-chlorophenyl)Methyl]aMino]carbonyl]-, 1,1-diMethylethyl ester, (2R)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Pyrrolidinecarboxylic acid, 2-[[[(4-chlorophenyl)Methyl]aMino]carbonyl]-, 1,1-diMethylethyl ester, (2R)-(1140495-84-6)
• EPA Substance Registry System: 1-Pyrrolidinecarboxylic acid, 2-[[[(4-chlorophenyl)Methyl]aMino]carbonyl]-, 1,1-diMethylethyl ester, (2R)-(1140495-84-6)

Safety Data

• Hazardous Substances Data: 1140495-84-6(Hazardous Substances Data)

Usage

Chemical classification

Ester derivative of pyrrolidinecarboxylic acid

Function

Pesticide and acaricide

Application

Control of pests and mites in agricultural settings

Mode of action

Inhibition of acetylcholinesterase enzyme activity

Effect on target organisms

Accumulation of acetylcholine in the nervous system, leading to paralysis and death

Safety concerns

Potential toxicity to humans and the environment

Handling precautions

Handle and use with caution

Upstream product

• 104-86-9 4-chlorobenzylamine 
• 37784-17-1 N-(tert-butoxycarbonyl)-D-proline 

Downstream Products

• 1140495-85-7 (R)-tert-butyl 2-((4-chlorobenzyl)carbamothioyl)pyrrolidine-1-carboxylate 
• 1123813-92-2 (R)-N-(4-chlorobenzyl)pyrrolidine-2-carboxamide 

Relevant articles and documents

Novel pyrrolidine heterocycles as CCR1 antagonists

A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptab

Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists

Monocyte infiltration is implicated in a variety of diseases including multiple myeloma, rheumatoid arthritis, and multiple sclerosis. C-C chemokine receptor 1 (CCR1) is a chemokine receptor that upon stimulation, particularly by macrophage inflammatory protein 1a (MIP-1a) and regulated on normal T-cell expressed and secreted (RANTES), mediates monocyte trafficking to sites of inflammation. High throughput screening of our combinatorial collection identified a novel, moderately potent CCR1 antagonist 3. The library hit 3 was optimized to the advanced lead compound 4. Compound 4 inhibited CCR1 mediated chemotaxis of monocytes with an IC50 of 20 nM. In addition, the compound was highly selective over other chemokine receptors. It had good microsomal stability when incubated with rat and human liver microsomes and showed no significant cytochrome P450 (CYP) inhibition. Pharmacokinetic evaluation of the compound in the rat showed good oral bioavailability.