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1140495-84-6

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1140495-84-6 Usage

Chemical classification

Ester derivative of pyrrolidinecarboxylic acid

Function

Pesticide and acaricide

Application

Control of pests and mites in agricultural settings

Mode of action

Inhibition of acetylcholinesterase enzyme activity

Effect on target organisms

Accumulation of acetylcholine in the nervous system, leading to paralysis and death

Safety concerns

Potential toxicity to humans and the environment

Handling precautions

Handle and use with caution

Check Digit Verification of cas no

The CAS Registry Mumber 1140495-84-6 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,0,4,9 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1140495-84:
(9*1)+(8*1)+(7*4)+(6*0)+(5*4)+(4*9)+(3*5)+(2*8)+(1*4)=136
136 % 10 = 6
So 1140495-84-6 is a valid CAS Registry Number.

1140495-84-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name tert-butyl (2R)-2-[(4-chlorophenyl)methylcarbamoyl]pyrrolidine-1-carboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1140495-84-6 SDS

1140495-84-6Relevant articles and documents

Novel pyrrolidine heterocycles as CCR1 antagonists

Merritt, J. Robert,James, Ray,Paradkar, Vidyadhar M.,Zhang, Chongwu,Liu, Ruiyan,Liu, Jinqi,Jacob, Biji,Chiriac, Camelia,Ohlmeyer, Michael J.,Quadros, Elizabeth,Wines, Pamela,Postelnek, Jennifer,Hicks, Catherine M.,Chen, Weiqing,Kimble, Earl F.,O'Brien, Linda,White, Nicole,Desai, Hema,Appell, Kenneth C.,Webb, Maria L.

supporting information; experimental part, p. 5477 - 5479 (2010/12/24)

A novel series of pyrrolidine heterocycles was prepared and found to show potent inhibitory activity of CCR1 binding and CCL3 mediated chemotaxis of a CCR1-expressing cell line. A potent, optimized triazole lead from this series was found to have acceptab

Novel pyrrolidine ureas as C-C chemokine receptor 1 (CCR1) antagonists

Merritt, J. Robert,Liu, Jinqi,Quadros, Elizabeth,Morris, Michelle L.,Liu, Ruiyan,Zhang, Rui,Jacob, Biji,Postelnek, Jennifer,Hicks, Catherine M.,Chen, Weiqing,Kimble, Earl F.,Rogers, W. Lynn,O'Brien, Linda,White, Nicole,Desai, Hema,Bansal, Shalini,King, George,Ohlmeyer, Michael J.,Appell, Kenneth C.,Webb, Maria L.

supporting information; experimental part, p. 1295 - 1301 (2009/12/07)

Monocyte infiltration is implicated in a variety of diseases including multiple myeloma, rheumatoid arthritis, and multiple sclerosis. C-C chemokine receptor 1 (CCR1) is a chemokine receptor that upon stimulation, particularly by macrophage inflammatory protein 1a (MIP-1a) and regulated on normal T-cell expressed and secreted (RANTES), mediates monocyte trafficking to sites of inflammation. High throughput screening of our combinatorial collection identified a novel, moderately potent CCR1 antagonist 3. The library hit 3 was optimized to the advanced lead compound 4. Compound 4 inhibited CCR1 mediated chemotaxis of monocytes with an IC50 of 20 nM. In addition, the compound was highly selective over other chemokine receptors. It had good microsomal stability when incubated with rat and human liver microsomes and showed no significant cytochrome P450 (CYP) inhibition. Pharmacokinetic evaluation of the compound in the rat showed good oral bioavailability.

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