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4-Chloropyridine-3-carboxaldehyde is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 114077-82-6 Structure
  • Basic information

    1. Product Name: 4-Chloropyridine-3-carboxaldehyde
    2. Synonyms: 4-CHLOROPYRIDINE-3-CARBOXALDEHYDE;4-CHLORO-3-FORMYLPYRIDINE;3-Pyridinecarboxaldehyde,4-chloro-(9CI);4-chloro-3-pyridincarboxaldehyde;4-Chloronicotinaldehyde;4-Chloro-3-pyridinecarboxaldehyde;4-chloropyridine-3-carbaldehyde;3-Pyridinecarboxaldehyde, 4-chloro-
    3. CAS NO:114077-82-6
    4. Molecular Formula: C6H4ClNO
    5. Molecular Weight: 141.56
    6. EINECS: N/A
    7. Product Categories: PYRIDINE;Building Blocks;Pyridines;pyridine series;Heterocycle-Pyridine series
    8. Mol File: 114077-82-6.mol
  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: 228.753 °C at 760 mmHg
    3. Flash Point: 92.147 °C
    4. Appearance: /
    5. Density: 1.332 g/cm3
    6. Vapor Pressure: 0.072mmHg at 25°C
    7. Refractive Index: 1.593
    8. Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
    9. Solubility: N/A
    10. PKA: 1.89±0.10(Predicted)
    11. CAS DataBase Reference: 4-Chloropyridine-3-carboxaldehyde(CAS DataBase Reference)
    12. NIST Chemistry Reference: 4-Chloropyridine-3-carboxaldehyde(114077-82-6)
    13. EPA Substance Registry System: 4-Chloropyridine-3-carboxaldehyde(114077-82-6)
  • Safety Data

    1. Hazard Codes: Xn
    2. Statements: 22-36-43
    3. Safety Statements: 26-36/37
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 114077-82-6(Hazardous Substances Data)

114077-82-6 Usage

Chemical Properties

White to light yellow powder

Check Digit Verification of cas no

The CAS Registry Mumber 114077-82-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,0,7 and 7 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 114077-82:
(8*1)+(7*1)+(6*4)+(5*0)+(4*7)+(3*7)+(2*8)+(1*2)=106
106 % 10 = 6
So 114077-82-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H4ClNO/c7-6-1-2-8-3-5(6)4-9/h1-4H

114077-82-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 4-Chloropyridine-3-carboxaldehyde

1.2 Other means of identification

Product number -
Other names 4-Chloro-3-pyridinecarboxaldehyde

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114077-82-6 SDS

114077-82-6Relevant articles and documents

Aromatizing olefin metathesis by ligand isolation inside a metal- organic framework

Vermeulen, Nicolaas A.,Karagiaridi, Olga,Sarjeant, Amy A.,Stern, Charlotte L.,Hupp, Joseph T.,Farha, Omar K.,Stoddart, J. Fraser

, p. 14916 - 14919 (2013)

The aromatizing ring-closing metathesis has been shown to take place inside an extended porous framework. Employing a combination of solvent-assisted linker exchange and postsynthesis modification using olefin metathesis, the noninterpenetrated SALEM-14 was formed and converted catalytically into PAH-MOF-1 with polycyclic aromatic hydrocarbon (PAH) pillars. The metal-organic framework in SALEM-14 prevents "intermolecular" olefin metathesis from occurring between the pillars in the presence of the first generation Hoveyda-Grubbs catalyst, while favoring the production of a PAH, which can be released from the framework under acidic conditions in dimethylsulfoxide.

A practical synthesis of 4-chloro-3-(hydroxymethyl)pyridine by regioselective one-pot lithiation/formylation/reduction of 4-chloropyridine

Albanese, Domenico,Penso, Michele,Zenoni, Maurizio

, p. 1294 - 1296 (1999)

4-Chloro-3-(hydroxymethyl)pyridine was prepared and isolated as its hydrochloride in 85% yield from 4-chloropyridine by formylation with dimethylformamide of the corresponding 3-lithium salt, followed by in situ reduction of the resulting 4-chloro-3-formylpyridine through a crossed- Cannizzaro reaction with aqueous formaldehyde.

Sulfur-containing amino acid feed additive and preparation method thereof

-

Paragraph 0018-0025, (2019/03/25)

The invention discloses a sulfur-containing amino acid feed additive and a preparation method thereof, and belongs to the technical field of synthesis of feed additives. The key point of the technicalscheme of the invention is as shown in specification. Compared with the prior art, the sulfur-containing amino acid feed additive has the beneficial effects that the synthetic method is simple, a molecular structure is novel, and can react with nickel ions in a protein target of urease, the urease is inhibited to a certain extent, and the sulfur-containing amino acid feed additive is expected tobe further popularized and used as a composite feed additive.

A 3 - aldehyde -4 - chloro pyridine green preparation method

-

Paragraph 0027-0032, (2019/03/25)

The invention discloses a 3 - aldehyde - 4 - chloro pyridine green preparation method, which belongs to the technical field of organic synthesis. Technical proposal of the invention points are: to pyridine as raw materials, the selective chlorination, after the adoption of the salt in the solvent impurities and product of different solubility, can be recrystallized separation, to obtain 4 - chloro pyridine pure product, finally is then subjected to an N, N - dimethyl formamide substitution reaction to obtain the 3 - aldehyde - 4 - chloro pyridine. The invention compared with the prior art has the following advantages: the invention synthetic method is simple, cheap price of raw materials, and is favorable for industrial production.

A 3 - aldehyde -4 - chloro pyridine preparation method

-

Paragraph 0025; 0026; 0027; 0028; 0029; 0030, (2019/03/25)

The invention discloses a 3 - aldehyde - 4 - chloro pyridine of the preparation method, which belongs to the technical field of organic synthesis. Technical proposal of the invention points are: to pyridine as raw materials, the selective chlorination of at first, through the molecular distillation treatment to obtain a pure 4 - chloro pyridine, then in N, N - dimethyl formamide substitution reaction to obtain the 3 - aldehyde - 4 - chloro pyridine. The invention compared with the prior art has the following advantages: the invention synthetic method is simple, cheap price of raw materials, and is favorable for industrial production.

NOVEL PYRAZOLE DERIVATIVE AS ALK5 INHIBITOR AND USES THEREOF

-

, (2019/05/16)

The present disclosure relates to a novel substituted pyrazole derivative having an effect of inhibiting serine/threonine kinase activity targeting receptor ALK5 of TGF-β, and a pharmaceutical composition including the compound of the present disclosure as an active ingredient may be useful in preventing and/or treating cancers, autoimmune diseases, fibrotic diseases, inflammatory diseases, neurodegenerative diseases, infectious diseases, pulmonary diseases, cardiovascular diseases or metabolic diseases, or other diseases associated with a decrease in TGF family signaling activity.

HETEROAROMATIC ELECTROPHILES AND METHODS OF USING THEREOF

-

Page/Page column 44, (2018/09/18)

Disclosed herein are compounds, compositions, and methods for reactivating or realkylating aged acetylcholinesterase inhibited by or conjugated to the organophosphorus compound. The organophosphorus compound can be a nerve agent. The acetylcholinesterase can be in the central nerve system (CNS) and/or the peripheral nervous system (PNS) of a subject. Accordingly, methods for ameliorating, diminishing, reversing, treating or preventing the toxic effects of an organophosphorus compound in a subject are provided herein. Methods for prophylactic or therapeutic treatment of exposure to an organophosphorus nerve agent are also provided.

NOVEL MORPHOLINE DERIVATIVE OR SALT THEREOF

-

, (2016/07/05)

There is provided a morpholine derivative represented by General Formula [1A] or a salt thereof. (In the formula, a ring A represents a ring represented by General Formula [I]; * represents a bonding position; Z2 represents CH or the like; Z1 represents CR6 or the like; R6 represents a hydrogen atom or the like; X1 represents CHR7 or the like; R7 represents a hydrogen atom or the like; X2 represents CH2 or the like; R1 and R2 are the same as or different from each other, and each of R1 and R2 represents a hydrogen atom or the like; R3, R4, and R5 are the same as or different from each other, and each of R3, R4, and R5 represents a hydrogen atom, NRaRb, or the like; and each of Ra and Rb represents a hydrogen atom, a C1-8 alkyl group which may have a substituent, or the like.)

SULFAMATE DERIVATIVE COMPOUND FOR USE IN PREVENTING OR TREATING EPILEPSY

-

Page/Page column 211, (2015/06/25)

The present invention relates to a pharmaceutical composition for treating or preventing epilepsy containing a sulfamate derivative compound and/or pharmaceutically acceptable salt thereof as an active ingredient. Furthermore, the present invention relates to a method for treatment or prevention epilepsy comprising administering a sulfamate derivative compound in a pharmaceutically effective amount to a subject in need of treatment or prevention of epilepsy.

Double palladium-catalyzed synthesis of azepines

Bo?inovi?, Nina,Opsenica, Igor,?olaja, Bogdan A.

supporting information, p. 49 - 52 (2013/02/23)

The synthesis of new 5H-pyridobenzazepine and 5H-dipyridoazepine compounds using as key step a palladium-catalyzed amination-cyclization reaction is reported. By choosing an appropriate combination of ligands and reactants under standardized reaction conditions, N- and S-tricyclic products can be prepared in one step from the appropriate stilbenes. Georg Thieme Verlag Stuttgart · New York.

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