114094-71-2

Upstream product

• 61699-62-5 diisopropyl squarate 
• 591-51-5 phenyllithium 
• 960-16-7 tributylphenylstannane 
• 130837-47-7 3-chloro-4-(1-methylethoxy)-3-cyclobutene-1,2-dione 
• 591-50-4 iodobenzene 
• 129034-70-4 4-(1-methylethoxy)-3-(tri-n-butylstannyl)cyclobut-3-ene-1,2-dione 
• 114094-64-3 2,3-bis(1-methylethoxy)-4-hydroxy-4-phenylcyclobut-2-en-1-one 

Downstream Products

• 141462-26-2 3-Isopropoxy-2-phenyl-4-hydroxy-4-phenyl-2-cyclobutenone 
• 304467-84-3 4-hydroxy-4-isopropenyl-3-isopropoxy-2-phenyl-cyclobut-2-enone 
• 334992-67-5 3-(3-methylbenzylamino)-4-phenylcyclobutene-1,2-dione 
• 1025889-42-2 4-Hydroxy-3-isopropoxy-2-phenyl-4-pyridin-2-yl-cyclobut-2-enone 

Relevant academic research and scientific papers

Anhydrous proton conductivities of squaric acid derivatives

In this communication, we introduce squaric acid derivatives as anhydrous proton conductors. We report the synthesis, characterization and proton conductivities of four squaric acid derivatives. The anhydrous proton conductivity of one of the derivatives

New synthesis of semisquaric acid derivatives via chlorinated N-(cyclobutylidene)amines

The synthesis and reactivity of new chlorinated AT-(cyclobutylidene)amines leading to new synthetic pathways toward various substituted cyclobutenediones is described.

General Enantiospecific Route to Isochromanquinones. Synthesis of (-)-Nanaomycin D

A general enantiospecific synthesis of isochromanquinones is presented.This entails an efficient synthesis of (3aS,5S,7aR)-7-bromo-3,3a,5,7a-tetrahydro-5-methyl-2H-furopyran-2-one (12) and ultimately the lithium agent 15 from commercially available L-rhamnose.Addition of 15 to the appropriate cyclobutenedione followed by thermolysis of the resulting cyclobutenone leads to the isochromanquinones 16a-c.In an analogous fashion the naturally occurring product, (-)-nanaomycin D, was synthesized.In addition, new methodology involving the ring expansion of iminocyclobutenones to aminophenols was discovered.

A General, Regioselective Synthesis of Substituted Benzocyclobutenedione Monoacetals

A general, regioselective synthesis of substituted benzocyclobutenedione monoacetals is reported.Palladium-catalyzed coupling of a variety of 4-chlorocyclobutenones with 3-(tri-n-butylstannyl)-3-cyclobutene-1,2-dione 2-(ethylene acetal) and heating up to

SYNTHESIS OF SUBSTITUTED CYCLOBUTENEDIONES BY THE PALLADIUM CATALYZED CROSS-COUPLING OF HALOCYCLOBUTENEDIONES WITH ORGANOSTANNANES

Halo-substituted cyclobutenediones undergo palladium catalyzed cross-coupling with organostannanes providing a mild method for the synthesis of substituted cyclobutenediones.

3-Stannylcyclobutenediones as Nucleophilic Cyclobutenedione Equivalents. Synthesis of Substituted Cyclobutenediones and Cyclobutenedione Monoacetals and the Beneficial Effect of Catalytic Copper Iodide on the Stille Reaction

Treatment of 3,4-diisopropoxycyclobutenedione with n-Bu3SnSiMe3/catalytic CN- furnished 3-isopropoxy-4-(tri-n-butylstannyl)cyclobutenedione in 65 percent yield.This compound cross-coupled with organic iodides attached to sp2- and sp-

An Improved Method for the Synthesis of Substituted Cyclobutenediones

Practical and high yielding routes to substituted cyclobutenediones are described. 3,4-Bis(1-methylethoxy)cyclobut-3-ene-1,2-dione (diisopropyl squarate), a stable, crystalline derivative of squaric acid, was easily prepared by refluxing squaric acid in 2