114121-68-5

Upstream product

• 3684-26-2 (S)-quinuclidin-3-ol 
• 852461-44-0 (R)-1-phenyl-1-cyclopentylethylene oxide 
• 25333-42-0 (R)-quinuclidin-3-ol 
• 184488-62-8 (S)-2-Cyclopentyl-2-phenyl-oxirane 
• 87827-02-9 benzenemethanol, α-[(1-azabicyclo[2.2.2]oct-3-yloxy)methyl]-α-cyclopentyl-hydrochloride 
• 114121-67-4 α-phenyl-α-cyclopentyloxirane 
• 1619-34-7 3-quinuclidinol 
• 64471-43-8 (S)-α-cyclopentyl-α-hydroxy-α-phenylacetic acid 
• 183201-50-5 (S)-1-Cyclopentyl-1-phenyl-ethane-1,2-diol 
• 852461-42-8 Toluene-4-sulfonic acid (S)-2-cyclopentyl-2-hydroxy-2-phenyl-ethyl ester 
• 427-49-6 2-cyclopentyl-2-hydroxy-2-phenylacetic acid 
• 910099-85-3 (2R,5S)-2-(tert-butyl)-5-phenyl-5-(cyclopent-1-enyl)-1,3-dioxolan-4-one 
• 909298-90-4 (2R,5S)-2-(tert-butyl)-5-phenyl-5-(1-hydroxycyclopentyl)-1,3-dioxolan-4-one 
• 116907-30-3 (2R,5R)-2-(tert-butyl)-5-phenyl-1,3-dioxolan-4-one 

Relevant academic research and scientific papers

Penehyclidine hydrochloride impurity and preparation method thereof

The invention relates to a penehyclidine hydrochloride impurity and a preparation method thereof, and belongs to the technical field of medicines. The penehyclidine impurity provided by the inventionis as shown in a formula I. The synthesis method of the impurity reference substance 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)quinine-1-oxide provided by the invention has the advantages of easily available synthesis raw materials, simple and convenient operation, low cost and good economic value.

Method for purifying 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy) quinuclidine and preparing penehyclidine hydrochloride

The invention provides a method for purifying 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy) quinuclidine and preparing penehyclidine hydrochloride. The method comprises the following steps: (1) mixing 3-quinuclidinol with a dimethyl sulfoxide solution, and r

CLASS OF BIFUNCTIONAL COMPOUNDS WITH QUATERNARY AMMONIUM SALT STRUCTURE

The invention provides a class of compounds represented by formula (I), having bifunctional active quaternary ammonium salt structure of a β2-adrenoreceptor agonist and an M receptor antagonist, a pharmaceutically acceptable salt, solvate, and optical isomer thereof. A pharmaceutical composition comprising such a compound with quaternary ammonium salt structure, a method for preparing such a compound with quaternary ammonium salt structure and an intermediate thereof, and uses thereof in treating pulmonary disorders are also provided. The compounds of the invention have high selectivity to the M receptor subtype, and have less adverse reaction and lower toxic and side effects in the treatment of pulmonary diseases such as COPD and asthma.

Quinine compound containing quaternary ammonium groups and preparation method of quinine compound

The invention discloses a quinine compound containing quaternary ammonium groups and a preparation method of the quinine compound, and relates to a novel compound with the general formula I and a preparation method of the novel compound. The preparation m

A quaternary ammonium salt of pentethyl quinamidine optical isomer, pharmaceutical composition and its medical use

The invention relates to a quaternary ammonium salt compound shown as a formula I, or pharmaceutically acceptable salt or solvate thereof. The invention also relates to application of the compound as a selective M receptor antagonist, particularly a selec

QUINUCLIDINE COMPOUNDS HAVING QUATERNARY AMMONIUM GROUP, IT'S PREPARATION METHOD AND USE AS BLOCKING AGENTS OF ACETYCHOLINE

The invention relates to the quinuclidine compounds of formula I having quaternary ammonium group, its preparation, and the pharmaceutical composition comprising an effective amount of the compound of formula I. The compound and the composition are used t

Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018)

A practical diastereoselective synthetic method for 8018 enantiopure isomers is described. The intramolecular asymmetric epoxidation of mono-sulfonate 4 was applied for the execution of the synthesis of the key chiral building block for the first time. The isomers were obtained with 70-76% yields in 99-100% ee.