183201-50-5

Upstream product

• 75366-33-5 1-cyclopentyl-1-phenylethene 
• 64471-43-8 (S)-α-cyclopentyl-α-hydroxy-α-phenylacetic acid 

Downstream Products

• 852461-42-8 Toluene-4-sulfonic acid (S)-2-cyclopentyl-2-hydroxy-2-phenyl-ethyl ester 
• 184488-62-8 (S)-2-Cyclopentyl-2-phenyl-oxirane 
• 114121-68-5 (S)-2-[(R)-(1-Aza-bicyclo[2.2.2]oct-3-yl)oxy]-1-cyclopentyl-1-phenyl-ethanol 
• 114121-68-5 (S)-2-[(S)-(1-Aza-bicyclo[2.2.2]oct-3-yl)oxy]-1-cyclopentyl-1-phenyl-ethanol 

Relevant academic research and scientific papers

Synthesis of the optical isomers of a new anticholinergic drug, penehyclidine hydrochloride (8018)

A practical diastereoselective synthetic method for 8018 enantiopure isomers is described. The intramolecular asymmetric epoxidation of mono-sulfonate 4 was applied for the execution of the synthesis of the key chiral building block for the first time. The isomers were obtained with 70-76% yields in 99-100% ee.