114149-93-8

Upstream product

• 67-56-1 methanol 
• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 114151-48-3 1-(4-Chlorophenyl)-6-hydroxyhexan-1,3-dione 

Downstream Products

• 114150-91-3 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl] propyl 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl] propionate 
• 114149-91-6 3-[5-(4-chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propanal 
• 114150-42-4 3-[5-(4-Chlorophenyl)-1-(4-methoxyphenyl)-3-pyrazolyl]propionic acid 

Relevant academic research and scientific papers

Differentiation of regioisomers at 15N natural abundance using gradient-enhanced 1H/15N HMBC NMR spectroscopy

The 1H/15N HMBC experiment at 15N natural abundance using pulsed field gradients is a useful tool for chemical shift assignment and structure elucidation. This experiment assisted in the identification of regioisomers that could not be distinguished with conventional 1H/1H nuclear Overhauser or 1H/13C correlation NMR experiments. The natural abundance 15N gradient-enhanced HMBC experiment was easily implemented, provided high-quality spectra and readily distinguished nitrogen-containing regioisomers. This experiment can aid in structure elucidation when traditional 1H and 13C experiments fail to provide unique structural assignment.

The Synthesis of 3-[3-(4-chlorophenyl)-1-(4-methoxyphenyl) -5-pyrazolyl]-N-hydroxy-N-methylpropanamide a regioisomer of tepoxalin

Compound 2 was synthesized in 4 steps in 65% overall yield. Mechanistic studies of the key pyrazole forming step revealed a tetrahyrofuran intermed.

1,5-Diaryl-3-substituted pyrazoles pharmaceutical compositions and use

1,5-Diaryl-3-substituted pyrazoles, a method of their preparation, compositions containing the same and methods of their use are disclosed. The pyrazoles are useful in alleviating inflammatory and cardiovascular disorders in mammals.