114185-08-9Relevant academic research and scientific papers
A stereocontrolled synthesis of (-)-detoxinine from L-ascorbic acid
Delle Monache, Giuliano,Misiti, Domenico,Zappia, Giovanni
, p. 2961 - 2973 (1999)
A stereoselective synthesis of (-)-detoxinine, the core unit of the detoxifying agent detoxin D1, is presented. The approach, characterized by the use of an inexpensive starting material and by the easy and stereoselective preparation of the ke
Stereoselective synthesis of the lichen metabolite, (+) montagnetol and its congeners as antimicrobial agents
Mallavadhani, Uppuluri Venkata,Boddu, Ramakrishna,Rathod, Balaji B.,Reddy Setty, Prakasam
supporting information, p. 2992 - 2999 (2018/10/15)
In view of structural diversity, (+) montagnetol, the major metabolite of the fruticose lichen, Roccella montagnei was synthesized along with three of its congeners by employing highly efficient protocols. (+) Montagnetol (2 R, 3S; 11) and (-) montagnetol (2S, 3R; 5) were synthesized in 7 and 9 steps, respectively, from L-ascorbic acid. The two new congeners 3 (2 R, 3R) and 6 (2S, 3S), which differ in configuration at C-2 and C-3 positions of the (+) montagnetol, were synthesized from (?) diethyl D-tartrate and (+) diethyl L-tartrate, respectively. The synthesized compounds were evaluated in vitro for antimicrobial activity against two Gram-positive (S. aureus and E. coli) and two Gram-negative (S. typhi and P. aeruginosa) bacteria and one fungal strain Candida albicans. Interestingly, the congener 3 showed promising anti-bacterial activity (MIC: 0.062 μg/ml) against P. aeruginosa, whereas the congener 6 displayed potent anti-fungal activity (MIC: 0.062 μg/ml) against C. Albicans.
A method of manufacturing an optical isomer [...]
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Paragraph 0043; 0044, (2017/04/11)
PROBLEM TO BE SOLVED: To asymmetrically synthesize constituent optically active substances of doranidazole and clarify pharmacological and physicochemical features of each of the optically active substances.SOLUTION: A method of producing a compound of st
A method of manufacturing an optical isomer [...]
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Paragraph 0049; 0050, (2017/05/10)
PROBLEM TO BE SOLVED: To provide a method of an asymmetric synthesis for a structural enantiomer of doranidazole, and an intermediate used for the manufacturing method.SOLUTION: There is provided a method of manufacturing 2-nitro imidazole derivative repr
