188923-23-1

Upstream product

• 501-53-1 benzyl chloroformate 
• 114185-08-9 ethyl (2S,3S)-2-O-benzoyl-3,4-O-isopropylidene-2,3,4-trihydroxybutanoate 
• 114185-09-0 (2S,3R)-1,2-isopropylidenedioxy-butan-3,4-diol 
• 114185-07-8 ethyl (2R)-2-[(1S)-3,3-dimethyl(2,4-dioxolanyl)]-2-hydroxyacetate 
• 205489-14-1 (2S)-2-amino-2-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]ethan-1-ol 
• 188923-22-0 (5R,6S)-6-benzyloxycarbonylamino-2,2-dimethyl-5-hydroxy-1,3-dioxepane 
• 119927-17-2 1,2-O-isopropylidene-4-O-(tert-butyldimethylsilyl)-L-threitol 
• 251339-15-8 (2R,3S)-3-N-benzyloxycarbonyl-4-tert-butyldimethylsilyloxy-1,2-isopropylidenedioxy-butane 
• 65-85-0 benzoic acid 
• 251339-14-7 (2R,3S)-3-azido-4-tert-butyldimethylsilyloxy-1,2-isopropylidenedioxy-butane 
• 188923-21-9 (5R,6S)-6-amino-2,2-dimethyl-1,3-dioxepan-5-ol acetate 

Downstream Products

• 1010702-05-2 (S)-2-(benzyloxycarbonylamino)-2-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)ethyl methanesulfonate 
• 251339-16-9 methyl (4S,5R,Z)-3-N-benzyloxycarbonyl-5,6-isopropylidene-2-hexenoate 
• 188923-24-2 (1R)-1-benzyloxycarbonylamino-1-[(4R)-2,2-dimethyl-1,3-dioxolane-4-yl]-2-phenylthioethane 

Relevant academic research and scientific papers

Method for producing pyrazole derivative

PROBLEM TO BE SOLVED: To provide a method for producing a pyrazole derivative. SOLUTION: There is provided the method for producing a pyrazole derivative by using a compound represented by formula (IIC), (IID) or (III) and a compound represented by formula (IV). SELECTED DRAWING: None COPYRIGHT: (C)2018,JPOandINPIT

ACYCLIC AMINE INHIBITORS OF NUCLEOSIDE PHOSPHORYLASES AND HYDROLASES

The invention relates to compounds of the general formula (I) which are inhibitors of purine nucleoside phosphorylases (PNPs) and/or nucleoside hydrolases (NHs). The invention also relates to the use of these compounds in the treatment of diseases and infections including cancer, bacterial infections, protozoal infections, and T-cell mediated disease and to pharmaceutical compositions containing the compounds.

(1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]-2-hydroxyethylammonium benzoate, a versatile building block for chiral 2-aminoalkanols: Concise synthesis and application to nelfinavir, a potent HIV-protease inhibitor

A concise synthesis of a versatile chiral C4 building block for 2- aminoalkanols, (1S)-1-[(4R)-2,2-dimethyl-1,3-dioxolan-4-yl]2- hydroxyethylammonium benzoate (1a), was described. 1 (1a and its enantiomener 1b) acted as four stereoisomers of optically active 2-amino-1,3,4- butanetriol. The versatility of 1 was demonstrated by its application to the practical synthesis of nelfinavir (2), a potent HIV-protease inhibitor, as well as by the stereospecific synthesis of three diastereomers of 2.

Production of amide derivatives and intermediate compounds therefor

A method for producing an amide derivative of the formula ?XV! STR1 wherein each symbol is as defined in the specification, and an enantiomer thereof, a novel intermediate useful for producing said compound and a production method thereof. The production method of the present invention is extremely easy and simple as compared to the conventional methods, and enables effective production of compound ?XV! at high yields, which includes compound ?XVI! having an HIV protease inhibitory action. In addition, the novel intermediates of the present invention are extremely useful as intermediates for producing not only the aforementioned compound ?XVI! but also compounds useful as X-ray contrast media.

A stereocontrolled synthesis of (-)-detoxinine from L-ascorbic acid

A stereoselective synthesis of (-)-detoxinine, the core unit of the detoxifying agent detoxin D1, is presented. The approach, characterized by the use of an inexpensive starting material and by the easy and stereoselective preparation of the ke