114209-14-2Relevant articles and documents
Rapid generation and safe use of carbenes enabled by a novel flow protocol with in-line IR spectroscopy
Müller, Simon T.R.,Murat, Aurélien,Maillos, Delphine,Lesimple, Patrick,Hellier, Paul,Wirth, Thomas
, p. 7016 - 7020 (2015)
A powerful new continuous process for the formation and use of donor/acceptor-substituted carbenes is described. The safety profile of diazo group transfer on methyl phenylacetate was determined including kinetic studies in batch and in flow using in-line
FeII-catalysed insertion reaction of α-diazocarbonyls into X-H bonds (X = Si, S, N, and O) in dimethyl carbonate as a suitable solvent alternative
Tanbouza, Nour,Keipour, Hoda,Ollevier, Thierry
, p. 31241 - 31246 (2019/10/19)
The insertion reaction of a broad range of diazo compounds into Si-H bonds was found to be efficiently catalysed by Fe(OTf)2 in an emerging green solvent i.e. dimethyl carbonate (DMC). The α-silylated products were obtained in good to excellent yields (up to 95%). Kinetic studies showed that the extrusion of N2 to form an iron carbene intermediate is rate-limiting. The iron-catalysed insertion reaction of methyl α-phenyl-α-diazoacetate into polar X-H bonds (S-H, N-H, and O-H) was also established in DMC.
Alternative Sm(II) Species-Mediated Cascade Coupling/Cyclization for the Synthesis of Oxobicyclo[3.1.0]hexane-1-ols
You, Bingxin,Shen, Mengmeng,Xie, Guanqun,Mao, Hui,Lv, Xin,Wang, Xiaoxia
supporting information, p. 530 - 533 (2018/02/10)
The allylSmBr/HMPA/MsOH system has been found to be an efficient reagent for the "ester-alkene" coupling/cyclization cascade of readily available α-allyloxy esters. Oxobicyclo[3.1.0]hexane-1-ols were thus prepared in good to excellent yields and diastereo
