75455-48-0

Upstream product

• 96-09-3 styrene oxide 
• 107-18-6 allyl alcohol 
• 93-56-1 phenylethane 1,2-diol 
• 70122-89-3 tert-butyl allyl carbonate 
• 114209-14-2 (1-allyloxy-1-methoxymethyl-but-3-enyl)-benzene 
• 4358-87-6 (RS)-methyl mandelate 

Downstream Products

• 110-17-8 (2E)-but-2-enedioic acid 
• 82668-85-7 4-methyl-2-phenyltetrahydrofuran 
• 74249-42-6 2-iodo-1-phenyl-1-((prop-2-enyl)oxy)ethane 
• 80997-79-1 2-phenyl-4-methylenetetrahydrofuran 
• 41927-30-4 2-methyl-4-phenylbutan-1-ol 
• 74249-40-4 2-allyloxy-2-phenylethyl tosylate 

Relevant academic research and scientific papers

Aniline-terephthalaldehyde resin p-toluenesulfonate (ATRT) as a highly efficient and reusable catalyst for alcoholysis, hydrolysis, and acetolysis of epoxides

Alcoholysis, hydrolysis, and acetolysis of epoxides were carried out in the presence of a catalytic amount of aniline-terephthalaldehyde resin p-toluenesulfonate (ATRT) to give the corresponding β-substituted alcohols in good yields. Alcoholysis and hydrolysis of epoxides catalyzed by ATRT proceeded faster than those by pyridinium p-toluenesulfonate (PPTS).

Mild regiospecific alcoholysis and aminolysis of epoxides catalyzed by zirconium(IV) oxynitrate

A regiospecific method for the ring-opening reaction of epoxides by the primary, secondary, tertiary alcohols, and aryl, aliphatic amines has been developed using non-toxic metal nitrate salt as a catalyst. The best results were obtained using zirconium(IV) oxynitrate among the various screened metal nitrate salts. The reported protocol works efficiently for styrene epoxide and aliphatic as well.

Graphite oxide: A simple and efficient solid acid catalyst for the ring-opening of epoxides by alcohols

A simple, efficient, and general procedure for the ring-opening of epoxides with various alcohols to give the corresponding β-alkoxy alcohols using graphite oxide (GO) as the catalyst, under very mild reaction conditions is described. The method proceeds in good to excellent yields and in short reaction times at room temperature under metal-free conditions.

A broadly applicable and practical oligomeric (salen)Co catalyst for enantioselective epoxide ring-opening reactions

The (salen)Co catalyst (4a) can be prepared as a mixture of cyclic oligomers in a short, chromatography-free synthesis from inexpensive, commercially available precursors. This catalyst displays remarkable enhancements in reactivity and enantioselectivity relative to monomeric and other multimeric (salen)Co catalysts in a wide variety of enantioselective epoxide ring-opening reactions. The application of catalyst 4a is illustrated in the kinetic resolution of terminal epoxides by nucleophilic ring-opening with water, phenols, and primary alcohols; the desymmetrization of meso epoxides by addition of water and carbamates; and the desymmetrization of oxetanes by intramolecular ring opening with alcohols and phenols. The favorable solubility properties of complex 4a under the catalytic conditions facilitated mechanistic studies, allowing elucidation of the basis for the beneficial effect of oligomerization. Finally, a catalyst selection guide is provided to delineate the specific advantages of oligomeric catalyst 4a relative to (salen)Co monomer 1 for each reaction class.

NOVEL BENZYL SULFONAMIDE COMPOUNDS USEFUL AS MOGAT-2 INHIBITORS

The present invention provides compounds of Formula I. Wherein Rl, L, and A are as described herein, or a pharmaceutical salt thereof, processes for preparing the compounds, and methods of treating a condition, such as hypertriglyceridemia, using the comp

Cooperative bronsted acid-type organocatalysis: alcoholysis of sytrene oxides

We present a mild and efficient method for the completely regioselective alcoholysis of styrene oxides utilizing a cooperative Bronsted acid- type organocatalytic system comprised of mandelic acid (1 mol %) and N,N'-bis-[3,5-bis-(trifluoromethyl)phenyl]-thiourea (1 mol %). Various styrene oxides are readily transformed into their corresponding ss-alkoxy alcohols in good to excellent yields at full conversion. Simple aliphatic and sterically demanding, as well as unsaturated and acid-sensitive alcohols can be employed.

Facile and highly selective deprotection of tert-butyldimethyl silyl ethers using sulfated SnO2 as a solid catalyst

Highly selective deprotection of tert-butyldimethylsilyl ethers at room temperature has been described using sulfated SnO2 as an efficient solid catalyst. Copyright Taylor & Francis Group, LLC.

Hydrophobic amplification of noncovalent organocatalysis

The effects of hydrogen-bonding organocatalysts and water for the acceleration of epoxide openings with a variety of nucleophiles are additive and lead to excellent yields of the catalyzed reactions in water. The Royal Society of Chemistry 2006.

Carbon tetrabromide: An efficient catalyst for regioselective ring opening of epoxides with alcohols and water

Epoxides undergo rapid ring opening with a range of alcohols in the presence of catalytic amount of carbon tetrabromide under mild and convenient conditions to afford the corresponding β-alkoxy alcohols and 1,2-diols in high yields with high regioselectivity. Georg Thieme Verlag Stuttgart.

A facile, catalytic, and environmentally benign method for selective deprotection of teri-butyldimethylsilyl ether mediated by phosphomolybdic acid supported on silica gel

An environmentally benign PMA supported on SiO2 is found to be an efficient catalyst for the chemoselective deprotection of TBDMS ethers under very mild conditions. Various labile functional groups such as isopropylidene acetal, OTBDPS, OTHP, Oallyl, OBn, alkene, alkyne, OAc, OBz, N-Boc, N-Cbz, N-Fmoc, mesylate, and azide are found to be stable under the reaction conditions. This "truly catalytic" heterogeneous reaction does not require aqueous workup, and the supported catalyst and the solvent can be readily recovered and recycled.