1142209-61-7

Basic information

• Product Name: 3-(5-{[(4-methoxyphenyl)amino]carbonyl}-1,3,4-thiadiazol-2-yl)propanoic acid
• Synonyms: 3-(5-{[(4-methoxyphenyl)amino]carbonyl}-1,3,4-thiadiazol-2-yl)propanoic acid;1,3,4-thiadiazole-2-propanoic acid, 5-[[(4-methoxyphenyl)amino]carbonyl]-;1,3,4-thiadiazole-2-propanoic acid, 5-[[(4-methoxyphenyl)a
• CAS NO: 1142209-61-7
• Molecular Formula: C13H13N3O4S
• Molecular Weight: 307.32502
• Mol File: 1142209-61-7.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-(5-{[(4-methoxyphenyl)amino]carbonyl}-1,3,4-thiadiazol-2-yl)propanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(5-{[(4-methoxyphenyl)amino]carbonyl}-1,3,4-thiadiazol-2-yl)propanoic acid(1142209-61-7)
• EPA Substance Registry System: 3-(5-{[(4-methoxyphenyl)amino]carbonyl}-1,3,4-thiadiazol-2-yl)propanoic acid(1142209-61-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1142209-61-7(Hazardous Substances Data)

Upstream product

• 108-30-5 succinic acid anhydride 
• 127719-64-6 N⁽¹⁾-(4-methoxyphenyl)-2-hydrazino-2-thioxoacetamide 
• 64-19-7 acetic acid 
• 717139-53-2 N-(4-methoxy-phenyl)-2-morpholin-4-yl-2-thioxo-acetamide 
• 22303-36-2 N-(4-methoxyphenyl)-2-chloroacetamide 

Relevant articles and documents

Novel agonists of free fatty acid receptor 1 (GPR40) based on 3-(1,3,4-thiadiazol-2-yl)propanoic acid scaffold

1,3,4-Thiadiazole was explored as a more polar, heterocyclic replacement for the phenyl ring in the 3-arylpropionic acid pharmacophore present in the majority of GPR40 agonists. Out of 13 compounds synthesized using a flexible, three-step protocol (involving no chromatographic purification), four compounds were confirmed to activate the target in micromolar concentration range. While the potency of the series should be subject of further optimization, the remarkable aqueous solubility and microsomal stability observed for the lead compound (8g) apparently attests to this new scaffold’s high promise in the GPR40 agonist field.