1142224-53-0

Basic information

• Product Name: (2-((1S)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol
• Synonyms: (2-((1S)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol
• CAS NO: 1142224-53-0
• Molecular Weight: 328.427
• Mol File: 1142224-53-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: (2-((1S)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-((1S)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol(1142224-53-0)
• EPA Substance Registry System: (2-((1S)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol(1142224-53-0)

Safety Data

• Hazardous Substances Data: 1142224-53-0(Hazardous Substances Data)

Upstream product

• 153580-03-1 5,5-dimethylcyclopent-1-en-1-yl trifluoromethanesulfonate 
• 1142224-41-6 methyl 3-bromo-4-(tetrahydro-2H-pyran-2-yloxy)benzoate 
• 4541-32-6 2,2-dimethylcyclopentanone 
• 1011531-89-7 2-(5,5-dimethylcyclopent-1-en-1-yl)-4,4,5,5-tetramethyl-1 ,3 ,2-dioxaborolane 
• 1142224-47-2 methyl 2-(5,5-dimethylcyclopent-1-en-1-yl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-carboxylate 
• 1142224-50-7 methyl 2-(2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate 
• 1142224-51-8 (2-((1R)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol 
• 29415-97-2 methyl 3-bromo-4-hydroxybenzoate 
• 14348-41-5 3-bromo-4-hydroxy-benzoic acid 
• 1142224-45-0 methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(trifluoromethylsulfonyloxy)benzoate 
• 1142224-42-7 methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-(tetrahydro-2H-pyran-2-yloxy)benzoate 
• 1142224-43-8 methyl 3-(5,5-dimethylcyclopent-1-enyl)-4-hydroxybenzoate 

Downstream Products

• 1142224-57-4 4-(chloromethyl)-2-((1S)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl 
• 1222088-92-7 (1R,2R)-6'-((2-((S)-2,2-dimethylcyclopentyl)-2'-fluoro-5'-methoxy-[1,1'-biphenyl]-4-yl)methoxy)-2',3'-dihydrospiro[cyclopropane-1,1'-indene]-2-carboxylic acid 

Relevant articles and documents

Discovery of AM-6226: A Potent and Orally Bioavailable GPR40 Full Agonist That Displays Efficacy in Nonhuman Primates

GPR40 (FFA1) is a G-protein-coupled receptor, primarily expressed in pancreatic islets and enteroendocrine L-cells, and, when activated, elicits increased insulin secretion only in the presence of elevated glucose levels. We recently reported the discovery of AM-1638 (2), a full agonist of GPR40. Herein, we present further structure-activity relationships progressing from AM-1638 (2) to AM-6226 (14) that possesses a profile acceptable for dosing cynomolgus monkeys. The GPR40 full agonist AM-6226 (14) is the first molecule to display significant glucose lowering in cynomolgus monkeys providing additional evidence that GPR40 full agonists afford access to a powerful mechanism for maintaining glycemic control.

SPIROCYCLIC GPR40 MODULATORS

The present invention provides compounds useful, for example, for treating metabolic disorders in a subject. Such compounds have the general formula IA, IB, I'A or I'B, where the definitions of the variables are provided herein. The present invention also