1142946-16-4

Usage

Uses

Used in Pharmaceutical Development:
4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]is used as a drug candidate for the development of new medications targeting a range of medical conditions. Its chemical structure suggests that it could potentially engage with biological targets, making it a valuable asset in the creation of innovative therapeutics.
Used in Research and Discovery:
In the field of medicinal chemistry, 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]- serves as a subject for research to explore its interactions with biological systems. Understanding its binding affinity, selectivity, and mechanism of action can provide insights into the development of more effective drugs and contribute to the advancement of pharmaceutical science.
Used in Drug Design and Optimization:
The unique structure of 4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]can be leveraged in drug design processes to create optimized molecules with improved pharmacokinetic and pharmacodynamic profiles. This may involve modifying its side chain or core structure to enhance its therapeutic potential and reduce potential side effects.
Used in Target Identification and Validation:
4H-Pyrrolo[2,3-d]pyriMidin-4-one, 3,7-dihydro-2-[[4-(4-Methyl-1-piperazinyl)phenyl]aMino]can be employed in biological assays and screenings to identify and validate novel targets for drug intervention. By assessing its interactions with various proteins and pathways, researchers can gain a better understanding of its potential therapeutic applications and the diseases it may be effective against.

Upstream product

• 52133-67-2 ethyl 2-cyano-4,4-diethoxybutyrate 
• 1143571-97-4 (Z)-tert-butyl (tert-butoxycarbonylamino)(4-(4-methylpiperazin-1-yl)phenylamino)methylenecarbamate 
• 16153-81-4 4-(4-Methyl-piperazino)-anilin 

Downstream Products

• 1142946-17-5 ⁽⁰⁸¹⁾C₀₇₅₀₅ 
• 1147014-90-1 N-(4-(4-methylpiperazin-1-yl)phenyl)-4-(2-o-tolylethynyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1147015-24-4 4-{[2-methyl-1-(1-methylethyl)-1H-benzimidazol-7-yl]ethynyl}-N-[4-(4-methylpiperazin-1-yl)phenyl]-7H-pyrrolo[2,3-d]pyrimidin-2-amine 
• 1147015-04-0 1-isopropyl-7-((2-(4-(4-methylpiperazin-1-yl)phenylamino)-7H-pyrrolo[2,3-d]pyrimidin-4-yl)ethynyl)-1H-indole-3-carbonitrile 

Relevant academic research and scientific papers

PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME

Provided herein are pyrrolopyrimide alkynyl compounds, and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.

PYRROLOPYRIMIDINE COMPOUNDS AND THEIR USE AS JANUS KINASE MODULATORS

Provided herein are pyrrolopyrimidine compounds of Formula (I) wherein R1 is a heteroaryl containing at least one S atom, and optionally substituted on a ring carbon by one, two, or three substituents each independently selected from the group consisting of : halo, hydroxyl, nitro, formyl, formamido, cyano, sulfonyl, carboxy, amino, amido, acylamino, carbamoyl, sulphamoyl, alkyl, alkenyl, CF3, ureido, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, carbaldehyde oxime, N -alkylsulphamoyl, N-alkylcarbamoyl, -OR13R11 or -R13R11; R2 is phenyl or pyridinyl, wherein R2 optionally substituted on a ring carbon by one, two, or three substituents each indenpendently selected from the group consisting of : halo, hydroxyl, cyano, nitro, formyl, formamido, carboxy, sulfonyl, amino, amido, -N- alkyl -amino, carbamoyl, sulphamoyl, CF3, ureido, alkyl, alkenyl, alkynyl, alkoxy, alkanoyl, alkoxycarbonyl, N-alkylsulphamoyl, N-alkylcarbamoyl, -OR11, -OR12R11, or -R12R11; and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.