1143571-97-4Relevant articles and documents
Discovery and optimization of a novel series of dyrk1b kinase inhibitors to explore a MEK resistance hypothesis
Kettle, Jason G.,Ballard, Peter,Bardelle, Catherine,Cockerill, Mark,Colclough, Nicola,Critchlow, Susan E.,Debreczeni, Judit,Fairley, Gary,Fillery, Shaun,Graham, Mark A.,Goodwin, Louise,Guichard, Sylvie,Hudson, Kevin,Ward, Richard A.,Whittaker, David
supporting information, p. 2834 - 2844 (2015/04/14)
Potent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.
PYRROLOPYRIMIDINE ALKYNYL COMPOUNDS AND METHODS OF MAKING AND USING SAME
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Page/Page column 65, (2009/05/30)
Provided herein are pyrrolopyrimide alkynyl compounds, and methods of making and using the same. Such compounds may be used in inflammatory or myeloproliferative disorders. The disclosure also provides for treating cancer.