114331-06-5

Basic information

• Product Name: H-LYS(Z)-OBZL HCL
• Synonyms: N-EPSILON-Z-L-LYSINE BENZYL ESTER HYDROCHLORIDE;N-EPSILON-CBZ-L-LYSINE BENZYL ESTER HYDROCHLORIDE;N-EPSILON-CARBOBENZOXY-L-LYSINE BENZYLESER HYDROCHLORIDE;N-EPSILON-CARBOBENZOXY-L-LYSINE BENZYL ESTER HYDROCHLORIDE;N-EPSILON-BENZYLOXYCARBONYL-L-LYSINE BENZYL ESTER HYDROCHLORIDE SALT;N-BENZYLOXYCARBONYL-L-LYSINE BENZYL ESTER HYDROCHLORIDE SALT;H-LYS(Z)-OBZL HCL;H-LYS(Z)-OBZL HYDROCHLORIDE
• CAS NO: 114331-06-5
• Molecular Formula: C₂₁H₂₆N₂O₄*ClH
• Molecular Weight: 406.9
• EINECS: 228-859-9
• Mol File: 114331-06-5.mol
• Article Data: 1

Chemical Properties

• Melting Point: 138-140 °C
• Boiling Point: 529.6°Cat760mmHg
• Flash Point: 274.1°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 1.45E-11mmHg at 25°C
• Storage Temp.: 0-6°C
• CAS DataBase Reference: H-LYS(Z)-OBZL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-LYS(Z)-OBZL HCL(114331-06-5)
• EPA Substance Registry System: H-LYS(Z)-OBZL HCL(114331-06-5)

Safety Data

• WGK Germany: 3
• RTECS: OL5685000
• Hazardous Substances Data: 114331-06-5(Hazardous Substances Data)

Usage

General Description

H-LYS(Z)-OBZL HCL is a chemical compound that is commonly used as a substrate for enzyme activity assays, particularly for the measurement of cathepsin K and L activities. It is a synthetic substrate that can be cleaved by cathepsin K and L, and its cleavage can be quantified using fluorescence or absorbance measurements. H-LYS(Z)-OBZL HCL is often used in drug discovery and development research, as well as in the study of lysosomal storage diseases and related disorders. As a research tool, H-LYS(Z)-OBZL HCL is valuable for understanding the mechanisms of lysosomal protease activity and for screening potential therapeutic compounds targeting these enzymes.

InChI:InChI=1/C21H26N2O4.ClH/c22-18(20(24)26-14-16-8-3-1-4-9-16)12-7-13-19(23)21(25)27-15-17-10-5-2-6-11-17;/h1-6,8-11,18-19H,7,12-15,22-23H2;1H/t18-,19+;

Upstream product

• 128972-27-0 Nα-carbobenzoxy-Nε-tert-butoxycarbonyl-2,6-diaminohexanoyl benzyl ester 
• 2389-60-8 Z-Lys(Boc)-OH 
• 100-39-0 benzyl bromide 

Downstream Products

• 97811-94-4 Gly-D-Phe-L-Lys 
• 70290-83-4 Z-Gly-Leu-Lys(-Z)-OCH₂Ph 
• 80680-98-4 (S)-6-Benzyloxycarbonylamino-2-[(R)-2-(2-benzyloxycarbonylamino-acetylamino)-4-methyl-pentanoylamino]-hexanoic acid benzyl ester 
• 71227-74-2 Gly-L-Phe-L-Lys 

Relevant articles and documents

Synthesis and Spectroscopic Properties of Fluorinated Coumarin Lysine Derivatives

The site-selective incorporation of fluorescent amino acids into proteins has emerged as a valuable alternative to expressible protein reporters. For successful application, a robust and scalable, yet flexible, route to non-natural amino acids is required. This work describes an improved synthesis of coumarin-conjugated lysine derivatives where fluorinated variants are accessed. These analogues can be utilized at low pH and should find application probing biological processes that operate under acidic conditions.